{"doi":"10.1016/j.cdnut.2025.107552","title":"The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study","abstract":"Background: Anthracycline chemotherapy (AC) leads to cardiotoxicity in many patients with breast cancer by inducing inner mitochondrial damage and disrupting the electron transport chain. It is unclear why some, but not all, women who undergo AC develop chronic cardiac dysfunction. Objectives: The aim of this prospective feasibility study was to determine accrual rate and estimate the effect size of 1 cycle of AC on myocardial injury and blood lipidome changes in women with breast cancer. Methods: Fourteen women with breast cancer planning to undergo AC enrolled and underwent cardiac magnetic resonance (CMR) imaging and blood sampling across 2 visits, before and after any 1 cycle of AC in the treatment regimen. Fatty acid composition of red blood cells (RBCs) and cardiolipin (CL) in peripheral blood mononuclear cells were measured. Exploratory analyses were conducted. Results: CL correlated positively with myocardial fibrosis, and OA content in RBCs correlated positively with myocardial edema. Conclusions: CL against AC.This trial was registered at clinicaltrials.gov as NCT03961685.","journal":"Current Developments in Nutrition","year":2025,"id":546635,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03961685"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":300105,"name":"Rachel M. Cole","orcid":null,"position":1,"is_corresponding":false},{"id":430239,"name":"Daniel Addison","orcid":"0000-0002-9113-8333","position":2,"is_corresponding":false},{"id":792642,"name":"Patrick Ruz","orcid":null,"position":3,"is_corresponding":false},{"id":605472,"name":"Genevieve C. Sparagna","orcid":"0000-0001-9543-4626","position":4,"is_corresponding":false},{"id":246202,"name":"Ai Ni","orcid":"0000-0003-3002-3556","position":5,"is_corresponding":false},{"id":298116,"name":"Martha A. Belury","orcid":"0000-0002-6480-4281","position":6,"is_corresponding":false},{"id":1438745,"name":"Kate Marris","orcid":null,"position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T02:53:32.285899Z","pmid":"41069420","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}