{"doi":"10.1016/j.cdnut.2025.107467","title":"The Role of Diet and Hormones on Taste: Low Carb Compared With Low Fat Study Findings","abstract":"Background As obesity rates escalate, weight-loss interventions, including low-carbohydrate (LC) and low-fat (LF) diets, have become popular. While both diets promote weight loss, the effect of LC and LF diets on taste preference and sensitivity is less well understood. Objective In this study, we sought to (1) compare sweet and salty taste detection thresholds and preferences following a two-week ad libitum LF diet compared to a LC diet, (2) determine whether sweet and salty taste detection thresholds and preferences were associated with body weight, BMI and blood pressure, tase relevant taste substrates (sodium and total sugar), intake, and hunger and satiety hormone s (i.e., ghrelin, leptin, PYY and GLP-1). Methods We analyzed and compared taste preference and detection after ad libitum, randomized, controlled inpatient feeding study (n = 18) comparing LC (10% carbohydrate, 75% fat and 15% protein) and LF (75% carbohydrate, 10% fat and 15% protein) diets. Taste measures and hormone levels were measured at the end of each dietary period. Results We found no significant differences in taste measures between the LC and LF diets. However, we did observe a negative association between salt preference and leptin levels during both LC (rs= 0.59; P < 0.01) and LF (rs = -0.47; P < 0.05) dietary period. Salt taste preference was also negatively correlated with GLP-1 after the LF diet (rs = -0.61; P < 0.01). The results of this post-test study suggest that taste measures do not differ between a two-week LC and LF diets. Conclusions The results suggest that taste measures do not differ following two-week LC and LF diets. However, the relationship between taste preference and hunger and satiety hormones should be explored further. Clinical Trial Registry number #NCT03878108; www.clinicaltrial.gov","journal":"Current Developments in Nutrition","year":2025,"id":552835,"datarank":0.10843552483759752,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.004463447753605709,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.004463447753605709,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9659,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03878108"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445415,"name":"Alexis T. Franks","orcid":"0000-0002-0550-334X","position":1,"is_corresponding":false},{"id":866984,"name":"Nafisa Nawal","orcid":null,"position":2,"is_corresponding":false},{"id":1449586,"name":"Meaghan C Steck","orcid":null,"position":3,"is_corresponding":false},{"id":325237,"name":"Ariana M. Chao","orcid":"0000-0001-5633-8973","position":4,"is_corresponding":false},{"id":312236,"name":"Carolyn Allen","orcid":"0000-0001-7494-7430","position":5,"is_corresponding":false},{"id":758153,"name":"Brianna E Brooks","orcid":null,"position":6,"is_corresponding":false},{"id":1449587,"name":"Monica Atkinson","orcid":null,"position":7,"is_corresponding":false},{"id":270255,"name":"Amber B. Courville","orcid":"0000-0002-1419-3937","position":8,"is_corresponding":false},{"id":251342,"name":"Juen Guo","orcid":"0000-0003-2876-5884","position":9,"is_corresponding":false},{"id":272693,"name":"Shanna Yang","orcid":null,"position":10,"is_corresponding":false},{"id":1449588,"name":"Marinza Marzouk","orcid":null,"position":11,"is_corresponding":false},{"id":270256,"name":"Valerie L. Darcey","orcid":"0000-0002-5053-4567","position":12,"is_corresponding":false},{"id":270254,"name":"Stephanie T. Chung","orcid":"0000-0001-6989-0417","position":13,"is_corresponding":false},{"id":270257,"name":"Ciarán G. Forde","orcid":"0000-0002-4001-9182","position":14,"is_corresponding":false},{"id":251344,"name":"Kevin D. Hall","orcid":"0000-0003-4062-3133","position":15,"is_corresponding":false},{"id":231551,"name":"Paule V. Joseph","orcid":"0000-0002-1198-9622","position":16,"is_corresponding":false},{"id":434708,"name":"Rosario B. Jaime-Lara","orcid":"0000-0002-5726-7529","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:54:37.527189Z","pmid":"40606290","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}