{"doi":"10.1016/j.cdnut.2024.103472","title":"Physicochemical Conditions Affecting Production of Cyclo(L-Phe-L-Pro), a Signal for Pathogenicity in the Food-Poisoning Pathogen Vibrio vulnificus","abstract":"retrieval.String samples from sections corresponding to the duodenum and jejunum were determined using pH analysis, presence of bile, and distance measurements.String and stool samples were stored at -80 C until analysis.Taxonomic classifications for microbiota from each sample were generated by 16S rRNA gene sequencing.Alpha and beta diversity metrics (e.g., composition, richness, diversity) were determined and differences between SI and stool assessed via independent t-tests.Results: Sampling of the SI was feasible and well-tolerated by participants.Duodenal and jejunal microbiotas were more similar to each other within than between individuals.The most prevalent taxa in the SI were Firmicutes/Streptococcus, Fusobacteria/Fusobacterium, and Actinobacteria/Actinomyces.The most prevalent taxa in stool were Firmicutes/Lachnospiraceae, Bacteroidetes/Bacteroides, and Firmicutes/Blautia.Mean bacterial richness (Sobs) nominally differed between SI and stool (66.5 AE 13.2 vs 55.1 AE 10.8, p0.07), but Shannon diversity (H) did not differ (3.2 AE 0.5 vs 3.2 AE 0.9, p0.92).Conclusions: In this pilot feasibility study, SI and stool microbiota differed in composition and richness, but not Shannon diversity.Additional analyses will be conducted to evaluate longitudinal changes in response to diet in the ongoing mini-MED trial.","journal":"Current Developments in Nutrition","year":2024,"id":500198,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1349556,"name":"Hae Ro Lee","orcid":null,"position":1,"is_corresponding":false},{"id":1349150,"name":"Kun‐Soo Kim","orcid":"0000-0002-5433-4175","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:04.829419Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}