{"doi":"10.1016/j.cdnut.2024.102760","title":"Dietary Plant to Animal Protein Ratio and Total and Cause-Specific Mortality in Two Prospective Cohort Studies","abstract":"Results: Compared with the total metabolite panel, the signature (204 metabolites) underrepresented lipids (45% vs 42%), overrepresented xenobiotics (11% vs 17%), with equal amino acid contribution (25%).The signature displayed enrichment of the glycine, serine, and threonine metabolism subpathway (FDR0.02),with a negative association of UPF intake with dimethylglycine (-0.006).Overall, each 10-percentagepoint increase in UPF intake corresponded to an average 0.79 SD difference in the signature (r 2 0.45; p < 0.0001).Each 1-SD increase in the signature was marginally associated with 1.21 (0.97, 1.52) higher odds of T2D over 6 years (526 cases).Significant associations were noted for persons with excess weight [OR: 1.28 (1.02, 1.60)] or the highest UPF intake: Puerto Ricans [OR: 2.10 (1.31, 3.35)], US mainland-born [OR: 2.40 (1.39, 4.10)], and in the lowest AHEI tertile [OR: 1.47 (1.03, 2.10)].Conclusions: A UPF metabolomics signature was adversely associated with T2D risk in Puerto Ricans, persons with US nativity, excess weight, or low diet quality.This association may be attributable to glycine, serine, and threonine metabolism disturbance, but biological mechanisms warrant further investigation.","journal":"Current Developments in Nutrition","year":2024,"id":500241,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8046,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1024474,"name":"Anne‐Julie Tessier","orcid":"0000-0003-4551-1640","position":1,"is_corresponding":false},{"id":896269,"name":"Fenglei Wang","orcid":"0000-0002-9496-0525","position":2,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":3,"is_corresponding":false},{"id":104573,"name":"Jorge E. Chavarro","orcid":"0000-0002-4436-9630","position":4,"is_corresponding":false},{"id":934859,"name":"Qi Sun","orcid":"0000-0002-1438-635X","position":5,"is_corresponding":false},{"id":104570,"name":"Walter C. Willett","orcid":"0000-0003-1458-7597","position":6,"is_corresponding":false},{"id":55362,"name":"Meir J. Stampfer","orcid":"0000-0001-8865-935X","position":7,"is_corresponding":false},{"id":860759,"name":"David J.A. Jenkins","orcid":"0000-0003-1192-9571","position":8,"is_corresponding":false},{"id":230952,"name":"Marta Guasch‐Ferré","orcid":"0000-0001-8525-1404","position":9,"is_corresponding":false},{"id":55333,"name":"Frank B. Hu","orcid":"0000-0002-8233-6274","position":10,"is_corresponding":false},{"id":856232,"name":"Andrea J. Glenn","orcid":"0000-0002-9302-2676","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:10:04.829419Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}