{"doi":"10.1016/j.cdnut.2024.102548","title":"Nutritional Modulation of Diet-Induced Obesity on Intestinal Barrier Dysfunction: Implications for Pancreatic Carcinogenesis","abstract":"Objectives: The gut-pancreas axis has been a topic of interest since it has been hypothesized that its alteration may be correlated with the development of certain types of diseases including pancreatic cancer. We have previously shown in a mouse model of pancreatic cancer [LSL-KrasG12D/+; p48Cre/+(KC)], that mice fed a high-fat diet (60% calories from fat) for 8 weeks: i) induced endotoxemia; ii) decreased colonic tight junction protein expression (ZO-1 and occludin); iii) increased colonic TLR-4 expression; iv) increased activation of redox-sensitive and TLR-4-triggered pathways, i.e.","journal":"Current Developments in Nutrition","year":2024,"id":500255,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9645,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1349217,"name":"Joanna Wirkus","orcid":"0000-0003-3532-2168","position":1,"is_corresponding":false},{"id":1349218,"name":"Aya Ead","orcid":"0000-0003-4909-5752","position":2,"is_corresponding":false},{"id":752434,"name":"Gerardo G. Mackenzie","orcid":"0000-0002-6460-7165","position":3,"is_corresponding":false},{"id":669918,"name":"Patricia I. Oteiza","orcid":"0000-0001-7462-1641","position":4,"is_corresponding":false},{"id":1349216,"name":"Jazmin Machuca","orcid":"0000-0002-8000-775X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:04.829419Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}