{"doi":"10.1016/j.cct.2023.107112","title":"Randomized trial protocol for remote monitoring for equity in advancing the control of hypertension in safety net systems (REACH-SNS) study","abstract":"BACKGROUND: Self-measured blood pressure monitoring (SMBP) is essential to effective management of hypertension. This study aims to evaluate effectiveness and implementation of SMBP that leverages: cellular-enabled home BP monitors without a need for Wi-Fi or Bluetooth; simple communication modalities such as text messaging to support patient engagement; and integration into existing team-based workflows in safety-net clinics. METHODS: This study will be conducted with patients in San Francisco who are treated within a network of safety-net clinics. English and Spanish-speaking patients with diagnosed hypertension will be eligible for the trial if they have recent BP readings ≥140/90 mmHg and do not have co-morbid conditions that make home BP monitoring more complex to manage. This study will implement a three-arm randomized controlled trial to compare varying levels of implementation support: 1) cellular-enabled BP monitors (with minimal implementation support), 2) cellular-enabled BP monitors with protocol-based implementation support (text reminders for patients; aggregated BP summaries sent to primary care providers), and 3) cellular-enabled BP monitors and pharmacist-led support (pharmacist coaching and independent medication adjustments). RESULTS: For the main analysis, we will use mixed effects linear regression to compare the change in primary outcome of systolic BP. Secondary outcomes include BP control (<140/90 mmHg), medication intensification, patient-reported outcomes, and implementation processes (i.e., engagement with the intervention). DISCUSSION: This study will design and test a digital health intervention for use in marginalized populations treated within safety net settings, evaluating both effectiveness and implementation to advance more equitable health outcomes.","journal":"Contemporary Clinical Trials","year":2023,"id":361660,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":356244,"name":"Elaine C. Khoong","orcid":"0000-0002-2514-3572","position":1,"is_corresponding":false},{"id":270730,"name":"Beverly B. Green","orcid":"0000-0003-3040-3436","position":2,"is_corresponding":false},{"id":251909,"name":"James D. Ralston","orcid":"0000-0001-6317-7987","position":3,"is_corresponding":false},{"id":1114413,"name":"Crystal Zhou","orcid":"0000-0002-0763-0721","position":4,"is_corresponding":false},{"id":1114414,"name":"Faviola Garcia","orcid":"0000-0003-3493-2984","position":5,"is_corresponding":false},{"id":19019,"name":"Charles E. McCulloch","orcid":"0000-0002-1279-6179","position":6,"is_corresponding":false},{"id":353553,"name":"Urmimala Sarkar","orcid":"0000-0003-4213-4405","position":7,"is_corresponding":false},{"id":360985,"name":"Courtney R. Lyles","orcid":"0000-0002-1111-8595","position":8,"is_corresponding":false},{"id":535329,"name":"Valy Fontil","orcid":"0000-0003-0795-3237","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T01:14:15.063476Z","pmid":"36738916","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}