{"doi":"10.1016/j.cct.2022.106994","title":"A study protocol for a cluster randomized pragmatic trial for comparing strategies for implementing primary HPV testing for routine cervical cancer screening in a large health care system","abstract":null,"journal":"Contemporary Clinical Trials","year":2023,"id":641405,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1667698,"name":"Nancy T. Cannizzaro","orcid":null,"position":1,"is_corresponding":false},{"id":85416,"name":"Erin E. Hahn","orcid":"0000-0002-8419-2331","position":2,"is_corresponding":false},{"id":1667700,"name":"Devansu Tewari","orcid":null,"position":3,"is_corresponding":false},{"id":1667701,"name":"Quyen Ngo-Metzger","orcid":null,"position":4,"is_corresponding":false},{"id":1667702,"name":"Chunyi Hsu","orcid":null,"position":5,"is_corresponding":false},{"id":474751,"name":"Ernest Shen","orcid":"0000-0001-6842-9418","position":6,"is_corresponding":false},{"id":1667703,"name":"Patricia Wride","orcid":null,"position":7,"is_corresponding":false},{"id":1667704,"name":"Melissa Hodeib","orcid":null,"position":8,"is_corresponding":false},{"id":1142180,"name":"Michael Gould","orcid":"0000-0003-2784-9576","position":9,"is_corresponding":false},{"id":419722,"name":"Brian S. Mittman","orcid":"0000-0003-3589-9178","position":10,"is_corresponding":false},{"id":1667695,"name":"Chun R. Chao","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A study protocol for a cluster randomized pragmatic trial for comparing strategies for implementing primary HPV testing for routine cervical cancer screening in a large health care system","abstract":"<h4>Background</h4>Limited guidance exists regarding implementation strategies that best facilitate cancer screening practice substitution and achieve optimal stakeholder-centered outcomes. Here we describe the protocol for a randomized pragmatic trial comparing two implementation strategies to facilitate substitution of primary HPV screening for Pap and HPV co-testing to perform routine cervical cancer screening of women aged 30-65 years at Kaiser Permanente Southern California (KPSC).<h4>Methods</h4>Twelve service areas within KPSC will be randomized to a \"centrally-administered system-wide implementation + local-tailored implementation\" strategy or a \"centrally-administered system-wide implementation only\" strategy. The centrally-administered strategy comprises clinician and staff educational activities. Sites in the local-tailored arm will then conduct a structured local needs assessment followed by site-specific selection and deployment of implementation interventions. Surveys and interviews will be conducted among women and providers from the primary care and ob/gyn departments prior to the system-wide transition, shortly after the transition, and after the completion of local-tailored interventions. A stakeholder advisory committee will assist with study design, defining stakeholder-centered outcomes, and developing data collection tools.<h4>Results</h4>The primary outcome of interest is uptake of primary HPV screening. Secondary provider-centered outcomes include provider knowledge, delivery of patient education, satisfaction with the practice substitution process, and resistance to primary HPV screening. Secondary patient-centered outcomes include patient knowledge, stigma, and satisfaction with the screening process. Intervention fidelity will also be measured via surveys.<h4>Conclusions</h4>Findings from this study will help inform future use of a local-tailored implementation strategy for adopting primary HPV screening at large health care systems. Findings may also be applicable to other types of practice substitution.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36336248","pmcid":null,"openalex_id":"https://openalex.org/W4308065823","authors":[],"funders":[{"funder_name":"Patient-Centered Outcomes Research Institute","grant_id":"CDR-2018C1-10987","title":null}],"total_grants":1,"fwci":0.2935,"citation_percentile":0.56790698,"influential_citations":0,"citation_trend":[{"year":2025,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1551714422003202?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1551714422003202?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cct.2022.106994","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36336248","host_type":"repository"}],"fields_of_study":["Cervical Cancer and HPV Research","Global Cancer Incidence and Screening","Health Policy Implementation Science","Female","Humans","Delivery of Health Care","Early Detection of Cancer","Mass Screening","Papillomavirus Infections","Randomized Controlled Trials as Topic","Uterine Cervical Neoplasms","Pragmatic Clinical Trials as Topic"],"mesh_terms":["Uterine Cervical Neoplasms","Delivery of Health Care","Female","Humans","Mass Screening","Randomized Controlled Trials as Topic","Papillomavirus Infections","Early Detection of Cancer","Pragmatic Clinical Trials as Topic"],"keywords":["Medicine","Psychological intervention","Stakeholder","Cluster randomised controlled trial","Service delivery framework","Randomized controlled trial","Family medicine","Nursing","Patient satisfaction","Protocol (science)","Service (business)","Alternative medicine","Implementation","Cervical Cancer Screening","Pragmatic Trial","Practice Change","Primary Hpv Screening","Local-tailoring"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T17:45:31.996156Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}