{"doi":"10.1016/j.cct.2021.106539","title":"The Nourish Protocol: A digital health randomized controlled trial to promote the DASH eating pattern among adults with hypertension","abstract":"INTRODUCTION: Over 100 million adults in the United States have hypertension. The DASH (Dietary Approaches to Stop Hypertension) eating pattern is an evidence-based first-line treatment option for hypertension; however, adherence to the DASH eating pattern at a population level remains low. To address this gap, we will implement Nourish, a randomized controlled efficacy trial that will leverage a commercially-available smartphone application and evidence-based behavior change principles to improve adherence to the DASH eating pattern among adults with hypertension. METHODS: The Nourish trial is a two-arm, 12-month randomized control trial that will enroll adults (N = 300) with hypertension, defined as a systolic blood pressure of 120-159 mmHg; a diastolic blood pressure of 80-99 mmHg; and/or adults on blood pressure-lowering medication. Nourish will test the efficacy of a digital health intervention, as compared to the attention control arm, on DASH eating pattern adherence and blood pressure. Intervention components will include skills training, self-monitoring, personalized feedback, and responsive coaching. The primary outcome of the trial is 6-month changes in adherence to the DASH eating pattern, as measured by 24-h dietary recalls. DISCUSSION: Millions of Americans remain in need of effective behavioral interventions to manage and improve their hypertension and its adverse consequences. The ubiquity of smartphones offers a promising approach to disseminate the DASH eating pattern. By leveraging these widely used smartphone applications, combined with evidence-based behavior change principles and the DASH eating plan, Nourish will demonstrate the effectiveness of a digital health intervention to improve DASH adherence, and ultimately, to reduce blood pressure. Trial Number: NCT03875.","journal":"Contemporary Clinical Trials","year":2021,"id":189349,"datarank":0.6386613793204264,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.22277307098445923,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.22277307098445923,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":10,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT00003875"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":751923,"name":"Miriam B. Berger","orcid":"0000-0001-7236-8734","position":1,"is_corresponding":false},{"id":464986,"name":"Sandy Askew","orcid":"0000-0002-4585-6115","position":2,"is_corresponding":false},{"id":464985,"name":"Melissa C. Kay","orcid":"0000-0002-9695-3126","position":3,"is_corresponding":false},{"id":285071,"name":"Christina M. Hopkins","orcid":"0000-0003-4660-6641","position":4,"is_corresponding":false},{"id":752674,"name":"Meghana Sai Iragavarapu","orcid":null,"position":5,"is_corresponding":false},{"id":752675,"name":"Mia de Leon","orcid":null,"position":6,"is_corresponding":false},{"id":752676,"name":"Megan Freed","orcid":null,"position":7,"is_corresponding":false},{"id":751924,"name":"Cherie Barnes","orcid":"0000-0003-4141-7171","position":8,"is_corresponding":false},{"id":266520,"name":"Qing Yang","orcid":"0000-0003-4844-4690","position":9,"is_corresponding":false},{"id":742450,"name":"Crystal C. Tyson","orcid":"0000-0003-2892-3790","position":10,"is_corresponding":false},{"id":432206,"name":"Laura P. Svetkey","orcid":"0000-0002-3675-1282","position":11,"is_corresponding":false},{"id":450778,"name":"Gary G. Bennett","orcid":"0000-0002-4740-9175","position":12,"is_corresponding":false},{"id":347435,"name":"Dori Steinberg","orcid":"0000-0001-7588-4216","position":13,"is_corresponding":false},{"id":721949,"name":"Hailey Miller","orcid":"0000-0001-6045-6542","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-18T23:49:18.604374Z","pmid":"34400362","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}