{"doi":"10.1016/j.ccr.2006.01.013","title":"X chromosomal abnormalities in basal-like human breast cancer","abstract":"Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.","journal":"Cancer Cell","year":2006,"id":63,"datarank":1.0178381467511894,"base_score":6.785587645007929,"endowment":6.785587645007929,"self_citation_contribution":1.0178381467511894,"citation_network_contribution":0.0,"self_endowment_contribution":1.0178381467511894,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":884,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0482,"is_oa":true,"file_count":1,"downloads":14,"has_version_chain":false,"published_date":"2006-02-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":440,"name":"Zhigang C. Wang","orcid":null,"position":1,"is_corresponding":false},{"id":441,"name":"Arcangela De Nicolo","orcid":"0000-0002-7275-5571","position":2,"is_corresponding":false},{"id":442,"name":"Xin Lu","orcid":null,"position":3,"is_corresponding":false},{"id":443,"name":"Myles Brown","orcid":"0000-0002-8213-1658","position":4,"is_corresponding":false},{"id":444,"name":"Alexander Miron","orcid":null,"position":5,"is_corresponding":false},{"id":445,"name":"Xiaodong Liao","orcid":"0000-0001-9230-5220","position":6,"is_corresponding":false},{"id":446,"name":"J. Dirk Iglehart","orcid":null,"position":7,"is_corresponding":false},{"id":447,"name":"David M. Livingston","orcid":"0000-0001-5765-6025","position":8,"is_corresponding":false},{"id":448,"name":"Shridar Ganesan","orcid":"0000-0002-5404-3044","position":9,"is_corresponding":false},{"id":449,"name":"Xin Lü","orcid":"0000-0002-6612-8352","position":10,"is_corresponding":false},{"id":439,"name":"Andrea L. Richardson","orcid":"0000-0001-5221-1094","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}