{"doi":"10.1016/j.ccell.2025.07.005","title":"Myeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer","abstract":"Immunotherapy has shown limited success in recurrent ovarian cancer (OC), with prognostic insights largely derived from treatment-naive tumors. We analyzed 697 tumor samples (566 primary and 131 recurrent) from 595 OC patients across five independent cohorts, capturing tumor-infiltrating lymphocytes (TILs) heterogeneity and identifying four immune phenotypes linked to prognosis and TIL:myeloid networks driving malignant progression. We found that in preclinical mouse models, mirroring inflamed human OCs, the recurrent Brca1 mut tumors maintained activated TILs:dendritic cells (DCs) niches but evaded immune control through upregulation of COX/PGE 2 signaling. Conversely, recurrent Brca1 wt tumors displayed loss of TILs:DCs niches and accumulated immunosuppressive tumor microenvironment (TME) networks featuring Trem2/ApoE high tumor associated macrophages (TAMs) and Nduf4l2 high / Galectin3 high malignant states. Recurrent tumors recapitulate the immunogenic landscapes of original cancers. Our findings reveal BRCA-dependent TIL:myeloid crosstalk as key to persistent immunogenicity in recurrent OC and propose new targets to enhance chemotherapy efficacy.","journal":"Cancer Cell","year":2025,"id":510021,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":623737,"name":"Fabrizio Benedetti","orcid":"0000-0002-9959-9142","position":1,"is_corresponding":false},{"id":321469,"name":"Aspram Minasyan","orcid":"0000-0002-0063-2513","position":2,"is_corresponding":false},{"id":629792,"name":"Mathieu Desbuisson","orcid":"0000-0003-1349-7469","position":3,"is_corresponding":false},{"id":528354,"name":"Paula Cunnea","orcid":"0000-0002-3699-4911","position":4,"is_corresponding":false},{"id":623735,"name":"Alizée J Grimm","orcid":"0000-0002-4662-5490","position":5,"is_corresponding":false},{"id":623741,"name":"Noémie Fahr","orcid":"0000-0002-4623-7869","position":6,"is_corresponding":false},{"id":1366042,"name":"Charlotte Capt","orcid":null,"position":7,"is_corresponding":false},{"id":1366043,"name":"Nicolas Rayroux","orcid":null,"position":8,"is_corresponding":false},{"id":1066456,"name":"Flavia De Carlo","orcid":null,"position":9,"is_corresponding":false},{"id":556245,"name":"D. 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