{"doi":"10.1016/j.ccell.2025.07.001","title":"Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity","abstract":"CD4 + T helper cells play an important role in adoptive T cell therapy (ACT) success, but it remains unclear which subset is most therapeutic and how they eliminate tumors. We find that tumor-specific Th17 cells eradicate melanoma more effectively than other CD4 + subsets and protect against distant metastases by unique orchestration of host immunity. Donor Th17 cells require host B cells —but not T cells— for tumor regression. Th17 cells induce B cell proliferation, activation, and differentiation, while B cells augment Th17 cell polyfunctionality by enhancing IL-21 production. Th17 and B cells colocalize in lymphoid tissues, where Th17 cells induce germinal centers and tumor-reactive antibodies via IL-21 production and CD40L costimulation. Furthermore, these tumor-specific antibodies provide partial protection against tumor challenge. Herein, we reveal that adoptively transferred Th17 cells cooperate with B cells to drive sustained immunity, demonstrating a role for endogenous B cell responses in effective CD4 + ACT.","journal":"Cancer Cell","year":2025,"id":512623,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9478,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314034,"name":"Hannah M. Knochelmann","orcid":"0000-0003-0644-123X","position":1,"is_corresponding":false},{"id":314036,"name":"Megan M. Wyatt","orcid":"0000-0003-1316-260X","position":2,"is_corresponding":false},{"id":1196928,"name":"Megen C Wittling","orcid":"0000-0002-3631-4955","position":3,"is_corresponding":false},{"id":957055,"name":"Natalie K. Horvat","orcid":"0000-0003-2789-8132","position":4,"is_corresponding":false},{"id":314035,"name":"Aubrey S. Smith","orcid":"0000-0003-3693-4262","position":5,"is_corresponding":false},{"id":314033,"name":"Guillermo O. Rangel Rivera","orcid":"0000-0001-9364-6385","position":6,"is_corresponding":false},{"id":1372178,"name":"Amalia M. Rivera Reyes","orcid":"0000-0003-3675-2936","position":7,"is_corresponding":false},{"id":1372755,"name":"Bhavana Pavuluri","orcid":null,"position":8,"is_corresponding":false},{"id":1057228,"name":"Soundharya Kumaresan","orcid":"0000-0001-5946-1678","position":9,"is_corresponding":false},{"id":401573,"name":"Pawel Muranski","orcid":"0000-0002-4446-6385","position":10,"is_corresponding":false},{"id":562875,"name":"Ayana T. Ruffin","orcid":"0000-0002-5837-5871","position":11,"is_corresponding":false},{"id":270264,"name":"Jeremy M. Boss","orcid":"0000-0002-2432-1840","position":12,"is_corresponding":false},{"id":328027,"name":"Gregory B. Lesinski","orcid":"0000-0002-8787-7678","position":13,"is_corresponding":false},{"id":314041,"name":"Chrystal M. Paulos","orcid":"0000-0002-0784-2601","position":14,"is_corresponding":false},{"id":1051887,"name":"Anna C. Cole","orcid":"0000-0002-2832-2824","position":0,"is_corresponding":true}],"reference_count":101,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40712565","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}