{"doi":"10.1016/j.ccell.2023.06.007","title":"Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling","abstract":"Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM), but inevitably induces poorly understood global changes in GBM and its microenvironment (TME) that promote radio-resistance and recurrence. Through a cell surface marker screen, we identified that CD142 (tissue factor or F3) is robustly induced in the senescence-associated β-galactosidase (SA-βGal)-positive GBM cells after irradiation. F3 promotes clonal expansion of irradiated SA-βGal+ GBM cells and orchestrates oncogenic TME remodeling by activating both tumor-autonomous signaling and extrinsic coagulation pathways. Intratumoral F3 signaling induces a mesenchymal-like cell state transition and elevated chemokine secretion. Simultaneously, F3-mediated focal hypercoagulation states lead to activation of tumor-associated macrophages (TAMs) and extracellular matrix (ECM) remodeling. A newly developed F3-targeting agent potently inhibits the aforementioned oncogenic events and impedes tumor relapse in vivo. These findings support F3 as a critical regulator for therapeutic resistance and oncogenic senescence in GBM, opening potential therapeutic avenues.","journal":"Cancer Cell","year":2023,"id":316989,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":87,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9636,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1021539,"name":"Jeong‐Yub Kim","orcid":"0000-0003-3459-126X","position":1,"is_corresponding":false},{"id":275916,"name":"Hee Jin Cho","orcid":"0000-0002-5247-6989","position":2,"is_corresponding":false},{"id":1022108,"name":"Won Jun Lee","orcid":null,"position":3,"is_corresponding":false},{"id":893626,"name":"Dayna Nguyen","orcid":null,"position":4,"is_corresponding":false},{"id":275920,"name":"Sung Soo Kim","orcid":"0000-0001-9214-9379","position":5,"is_corresponding":false},{"id":275923,"name":"Young Taek Oh","orcid":"0000-0001-8356-2428","position":6,"is_corresponding":false},{"id":902778,"name":"Hee‐Jin Kim","orcid":"0000-0003-3741-4613","position":7,"is_corresponding":false},{"id":1022109,"name":"Chan‐Woong Jung","orcid":null,"position":8,"is_corresponding":false},{"id":477112,"name":"Gonzalo Piñero","orcid":"0000-0001-8510-9598","position":9,"is_corresponding":false},{"id":630183,"name":"Tanvi Joshi","orcid":"0009-0001-5051-7927","position":10,"is_corresponding":false},{"id":305861,"name":"Dolores Hambardzumyan","orcid":"0000-0003-1975-4665","position":11,"is_corresponding":false},{"id":89673,"name":"Takuya Sakaguchi","orcid":"0000-0002-8422-0902","position":12,"is_corresponding":false},{"id":88688,"name":"Christopher G. Hubert","orcid":"0000-0002-1030-8549","position":13,"is_corresponding":false},{"id":344668,"name":"Thomas M. McIntyre","orcid":"0000-0001-7802-5900","position":14,"is_corresponding":false},{"id":251175,"name":"Howard A. Fine","orcid":"0000-0002-6169-5702","position":15,"is_corresponding":false},{"id":866186,"name":"Candece L. Gladson","orcid":"0000-0002-7651-4046","position":16,"is_corresponding":false},{"id":365362,"name":"Bingcheng Wang","orcid":null,"position":17,"is_corresponding":false},{"id":336895,"name":"Benjamin Purow","orcid":"0000-0001-7372-6062","position":18,"is_corresponding":false},{"id":1021540,"name":"Jong Bae Park","orcid":"0000-0003-0207-0697","position":19,"is_corresponding":false},{"id":1021541,"name":"Myung Jin Park","orcid":"0000-0002-1996-4083","position":20,"is_corresponding":false},{"id":254087,"name":"Do‐Hyun Nam","orcid":"0000-0002-8477-6791","position":21,"is_corresponding":false},{"id":275929,"name":"Jeongwu Lee","orcid":"0000-0002-5973-0687","position":22,"is_corresponding":false},{"id":650812,"name":"Hye-Min Jeon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":98,"raw_metadata":null,"created_at":"2026-07-19T01:06:44.698773Z","pmid":"37451272","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}