{"doi":"10.1016/j.ccell.2023.04.005","title":"Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer","abstract":"Most patients with blood cancer have reduced humoral and cellular immunity against SARS-CoV-2 variants following COVID-19 vaccination,1Fendler A. Shepherd S.T.C. Au L. Wilkinson K.A. Wu M. Schmitt A.M. Tippu Z. Farag S. Rogiers A. Harvey R. et al.Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer.Cancer Cell. 2022; 40: 438https://doi.org/10.1016/j.ccell.2022.03.010Abstract Full Text Full Text PDF PubMed Scopus (9) Google Scholar,2Fendler A. Shepherd S.T.C. Au L. Wu M. Harvey R. Schmitt A.M. Tippu Z. Shum B. Farag S. Rogiers A. et al.Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer.Lancet. 2022; 399: 905-907https://doi.org/10.1016/S0140-6736(22)00147-7Abstract Full Text Full Text PDF PubMed Scopus (53) Google Scholar so they are at increased risk of severe outcomes from COVID-19 infection and contribute disproportionately to ongoing COVID-19-related mortality.3(ONS), O.f.N.SPre-existing Conditions of people who died due to COVID-19, England and Wales.https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/datasets/preexistingconditionsofpeoplewhodiedduetocovid19englandandwalesDate: 2022Google Scholar As most restrictions to curb the spread of COVID-19 have lifted, this vulnerable patient group relies on existing COVID-19 therapeutics, including monoclonal antibodies (mAb) and antivirals, in both pre- and post-exposure contexts. However, ongoing evolution of Spike in Omicron subvariants has reduced neutralizing capacity of mAb therapies in laboratory assays, leading the World Health Organization (WHO) and the US Food and Drug Administration (FDA) to recommend against the use of some of these agents.4WHO Therapeutics and COVID-19: living guideline.https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2022.5Date: 2022Google Scholar Antiviral therapies such as nirmatrelvir and ritonavir (Paxlovid) are likely to retain activity against current Omicron subvariants, but they are contraindicated in patients receiving cytochrome P450 (CYP) 3A4 or P-glycoprotein-interacting therapies thus limiting their use in those receiving corticosteroids, antifungals, and many systemic anticancer therapies. Taken together, vulnerable patient groups are left with few therapeutic options, and this highlights a requisite for continual surveillance and re-assessment of available products in a rapidly evolving SARS-CoV-2 variant landscape. We report follow-up findings from CAPTURE (NCT03226886)—a prospective longitudinal cohort study assessing functional immune responses following infection and vaccination in patients with cancer. We previously reported that a proportion of patients with blood cancer do not have detectable neutralizing antibody titers (NAbTs) against Omicron variants even after four vaccine doses.5Fendler A. Shepherd S.T.C. Au L. Wu M. Harvey R. Wilkinson K.A. Schmitt A.M. Tippu Z. Shum B. Farag S. et al.Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer.Cell Rep. Med. 2022; 3100781https://doi.org/10.1016/j.xcrm.2022.100781Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar Here, we developed an in vitro assay utilizing acoustic liquid dispensing technology to accurately transfer nanoliters of concentrated mAbs at clinically relevant concentrations into the sera of 79 patients with blood cancer (Table S1) vaccinated with a third and/or fourth vaccine dose (BNT162b2), then measured the resulting NAbTs against Omicron variants in our good clinical practice (GCP)-compliant high-throughput live-virus microneutralization assay. Sera of 116 patients with solid cancer after three vaccine doses (BNT162b2) were used as controls (Table S1). To establish the neutralizing activity of the licensed mAb therapies, we generated extensive dose-response curves using over 3","journal":"Cancer Cell","year":2023,"id":349358,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":620656,"name":"Scott T.C. 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