{"doi":"10.1016/j.cccb.2021.100019","title":"Hippocampal atrophy and cognitive function in transient ischemic attack and minor stroke patients over three years","abstract":"Transient ischemic attack (TIA) and minor ischemic stroke (IS) is associated with a increased risk of late life dementia. In this study we aim to study the extent to which the rates of hippocampal atrophy in TIA/IS differ from healthy controls, and how they are correlated to neuropsychological measurements. TIA or minor stroke patients were tested with a neuropsychological battery including tests of executive function, and verbal and non-verbal memory at three time points out to 3 years. Annualized rates of hippocampal atrophy in TIA/IS patients were compared to controls. A linear-mixed regression model was used to assess the difference in rates of hippocampal atrophy after adjusting for time and demographic characteristics. TIA/IS patients demonstrated a higher hippocampal atrophy rate than healthy controls over a 3-year interval: the annual percentage change of the left hippocampal volume was 2.5% (78 mm3 per year (SD 60)) for TIA/IS patients compared to 0.9% (29 mm3 per year (SD 32)) for controls (p < 0.01); and the annual percentage change of the right hippocampal volume was 2.5% (80 mm3 per year (SD 46)) for TIA/IS patients compared to 0.5% (17 mm3 per year (SD 33)) for controls (P < 0.01). Patients with higher annual hippocampal atrophy were more likely to report higher TMT B times, but lower ROC total score, lower California Verbal Learning Test-II total recall, and lower ROC Figure recall scores longitudinally. TIA/IS patients experience a higher rate of hippocampal atrophy independent of TIA/IS recurrence that are associated with changes in episodic memory and executive function over 3 years.","journal":"Cerebral Circulation - Cognition and Behavior","year":2021,"id":199218,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":613875,"name":"Sean M. Nestor","orcid":"0000-0002-8848-5027","position":1,"is_corresponding":false},{"id":775196,"name":"Meng Wang","orcid":"0009-0001-7987-8953","position":2,"is_corresponding":false},{"id":66781,"name":"Pauline Wu","orcid":null,"position":3,"is_corresponding":false},{"id":775669,"name":"Jake Ursenbach","orcid":null,"position":4,"is_corresponding":false},{"id":775670,"name":"Amlish Munir","orcid":null,"position":5,"is_corresponding":false},{"id":210580,"name":"Rani Gupta","orcid":null,"position":6,"is_corresponding":false},{"id":775671,"name":"Sah Sana Tariq","orcid":null,"position":7,"is_corresponding":false},{"id":268016,"name":"Eric E. Smith","orcid":"0000-0003-3956-1668","position":8,"is_corresponding":false},{"id":605515,"name":"Richard Frayne","orcid":"0000-0003-0358-1210","position":9,"is_corresponding":false},{"id":431865,"name":"Sandra E. Black","orcid":"0000-0001-7093-8289","position":10,"is_corresponding":false},{"id":775672,"name":"Tolupe Sajobi","orcid":null,"position":11,"is_corresponding":false},{"id":775197,"name":"Shelagh B. Coutts","orcid":"0000-0001-5090-5105","position":12,"is_corresponding":false},{"id":715830,"name":"Philip A. Barber","orcid":"0000-0002-6051-1078","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:50:36.595945Z","pmid":"36324718","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}