{"doi":"10.1016/j.cca.2024.119949","title":"Clinical performance evaluation of an HIV Duo assay: From HIV screening to acute and non-acute HIV infection detection","abstract":null,"journal":"Clinica Chimica Acta","year":2025,"id":604434,"datarank":0.2529681398744475,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.011552453009332421,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.011552453009332421,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1172747,"name":"Chongyang Wu","orcid":"0009-0005-5504-3627","position":1,"is_corresponding":false},{"id":1042608,"name":"Yulin Yuan","orcid":"0000-0002-8449-1729","position":2,"is_corresponding":false},{"id":258081,"name":"Dongdong Li","orcid":"0000-0001-7464-6478","position":3,"is_corresponding":false},{"id":1550815,"name":"Jinli Lou","orcid":null,"position":4,"is_corresponding":false},{"id":491769,"name":"Xia Feng","orcid":"0000-0003-2460-192X","position":5,"is_corresponding":false},{"id":377703,"name":"Qiuwei Lu","orcid":null,"position":6,"is_corresponding":false},{"id":1550816,"name":"Rongcai Wu","orcid":null,"position":7,"is_corresponding":false},{"id":1550817,"name":"An-Jou Chen","orcid":null,"position":8,"is_corresponding":false},{"id":1550818,"name":"Chuanmin Tao","orcid":null,"position":9,"is_corresponding":false},{"id":237857,"name":"Xin Liu","orcid":"0000-0003-0847-182X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Clinical performance evaluation of an HIV Duo assay: From HIV screening to acute and non-acute HIV infection detection","abstract":"BACKGROUND: Evaluating the clinical performance of Elecsys HIV Duo assay for primary human immunodeficiency virus (HIV) screening and acute HIV infection detection. METHODS: This study was conducted from April 2022 to April 2023 and involved two distinct populations. For the HIV screening population, three HIV Duo results [HIV Duo, HIV antigen (Ag), and HIV antibody (Ab)] in primary screening were obtained (January 2021 to June 2021). In the diagnosed HIV population, retrospective samples from November 2016 to March 2023 were measured. RESULTS: The HIV screening population included 111,383 samples from a real-world screening program. The assay demonstrated a specificity of 99.91 % (95 % CI: 99.89 %, 99.93 %) and a PPV of 0.8516 (95 % CI: 0.8225, 0.8776). Regarding the diagnosed HIV population, 836 HIV patients were enrolled, including 14 acute HIV infectious patients with only HIV Ag + and a Western Blot (WB) confirmation rate of 0 %. The median (IQR) of the numeric cut-off index (COI) ratios of HIV Duo Ab and Ag significantly differed among the Ag + Ab-, Ag-Ab+, and Ag + Ab + subgroups. CONCLUSION: The Elecsys HIV Duo assay is suitable for primary HIV screening and can be integrated into a novel laboratory HIV testing algorithm to improve acute HIV detection in Chinese clinical practice. ABBREVIATIONS: HIV, Human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome; Ag, antigen; Ab, antibody; WB, Western Blot; COI, numeric cut-off index; CI, confidence interval; NAT, nucleic acid tests; EDC, electronic data capture systems; CDC, Chinese Centers for Disease Control and Prevention; IQR, interquartile range; PPV, positive predictive value; HCV, hepatitis C virus; HBV, hepatitis B virus; CI, confidence interval; ND, not able to define; F, female; M, male.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39241902","pmcid":null,"openalex_id":"https://openalex.org/W4402219777","authors":[],"funders":[],"total_grants":0,"fwci":0.9428,"citation_percentile":0.73232413,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.cca.2024.119949","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cca.2024.119949","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0009898124022022?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0009898124022022?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39241902","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS Research and Interventions","HIV/AIDS drug development and treatment","Humans","HIV Infections","Male","Female","HIV Antibodies","Retrospective Studies","Adult","Middle Aged","HIV Antigens","Mass Screening","Acute Disease","HIV Testing"],"mesh_terms":["HIV Testing","Acute Disease","Adult","Female","Humans","Male","Mass Screening","Middle Aged","Retrospective Studies","HIV Antibodies","HIV Antigens","HIV Infections"],"keywords":["Human immunodeficiency virus (HIV)","HIV screening","Medicine","Virology","Screening test","Immunology","Pediatrics","Men who have sex with men","Syphilis","P24 antigen","Acute Hiv Infection","Diagnostic Testing Algorithm","Hiv Duo"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:08:44.948103Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}