{"doi":"10.1016/j.cca.2023.117703","title":"Soluble PILRα: A novel plasma biomarker for atrial fibrillation progression and recurrence after catheter ablation","abstract":null,"journal":"Clinica Chimica Acta","year":2024,"id":613947,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1581857,"name":"Jingmeng Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1581858,"name":"Yangyang Bao","orcid":null,"position":2,"is_corresponding":false},{"id":1581860,"name":"Tianyou Ling","orcid":null,"position":3,"is_corresponding":false},{"id":1581862,"name":"Changjian Lin","orcid":null,"position":4,"is_corresponding":false},{"id":599187,"name":"Wenqi Pan","orcid":null,"position":5,"is_corresponding":false},{"id":921484,"name":"Ning Zhang","orcid":"0000-0003-2095-5261","position":6,"is_corresponding":false},{"id":584115,"name":"Yue Wei","orcid":"0000-0002-2288-8405","position":7,"is_corresponding":false},{"id":900472,"name":"Yun Xie","orcid":"0000-0002-4341-7426","position":8,"is_corresponding":false},{"id":1406139,"name":"Zimo Sha","orcid":null,"position":9,"is_corresponding":false},{"id":603440,"name":"Xiang Li","orcid":"0000-0003-0724-0982","position":10,"is_corresponding":false},{"id":1581866,"name":"Guanhua Wu","orcid":"0009-0007-7567-7082","position":11,"is_corresponding":false},{"id":1581867,"name":"Qiujing Chen","orcid":null,"position":12,"is_corresponding":false},{"id":1363458,"name":"Lin Lu","orcid":"0000-0003-0145-8008","position":13,"is_corresponding":false},{"id":1151354,"name":"Qi Jin","orcid":"0009-0006-1483-6142","position":14,"is_corresponding":false},{"id":235202,"name":"Yang Dai","orcid":"0000-0003-4365-4875","position":15,"is_corresponding":false},{"id":1581868,"name":"Liqun Wu","orcid":null,"position":16,"is_corresponding":false},{"id":1581856,"name":"Taojie Zhou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Soluble PILRα: A novel plasma biomarker for atrial fibrillation progression and recurrence after catheter ablation","abstract":"BACKGROUND: We aimed to identify plasma biomarkers of atrial fibrillation (AF) progression and recurrence after catheter ablation. METHODS: Using AF gene profiling data from GEO database, a weighted gene co-expression network analysis (WGCNA) was conducted to determine the most significant module and hub genes associated with AF. Subsequently, 318 consecutively admitted patients who had undergone radiofrequency catheter ablation were enrolled in this study. RESULTS: WGCNA results revealed that paired immunoglobulin-like type 2 receptor alpha (PILRA) was the only black module gene highly correlated with clinical traits. Plasma soluble PILRα (sPILRα) levels were elevated in patients with AF and significantly elevated in patients with persistent versus paroxysmal AF (4.64 ± 2.74 vs. 3.04 ± 1.56 ng/mL, p < 0.001). Elevated sPILRα level was an independent risk factor for AF progression even after adjusting for traditional factors (adjusted odds ratio: 3.06, 95 % confidence interval [CI]: 1.88-5.27, p < 0.001) and AF recurrence after catheter ablation in patients with persistent AF (adjusted hazards ratio: 4.41, 95 % CI: 1.22-15.92, p = 0.023). CONCLUSIONS: WGCNA screening of GEO microarray gene profiling data showed PILRA expression levels to be correlated with AF progression and recurrence after catheter ablation in patients with persistent AF.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38097129","pmcid":null,"openalex_id":"https://openalex.org/W4389613079","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81870250","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81900290","title":null}],"total_grants":2,"fwci":0.355,"citation_percentile":0.64889573,"influential_citations":0,"citation_trend":[{"year":2024,"count":2}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.cca.2023.117703","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cca.2023.117703","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0009898123005053?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0009898123005053?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38097129","host_type":"repository"}],"fields_of_study":["Atrial Fibrillation Management and Outcomes","Parathyroid Disorders and Treatments","Cardiac Fibrosis and Remodeling","Humans","Atrial Fibrillation","Treatment Outcome","Recurrence","Risk Factors","Catheter Ablation","Biomarkers"],"mesh_terms":["Atrial Fibrillation","Humans","Recurrence","Risk Factors","Biomarkers","Treatment Outcome","Catheter Ablation"],"keywords":["Atrial fibrillation","Biomarker","Catheter ablation","Cardiology","Internal medicine","Ablation","Medicine","Chemistry","Biochemistry","Recurrence","Weighted Gene Co-expression Network Analysis","Microarray Gene Profiling","Soluble Paired Immunoglobulin-like Type 2 Receptor Alpha"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T09:49:06.946978Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}