{"doi":"10.1016/j.cbpa.2023.111452","title":"Sodium current preserves electrical excitability in the heart of hibernating ground squirrel (Citellus undulatus)","abstract":null,"journal":"Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology","year":2023,"id":606597,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1557312,"name":"Vladislav S. Kuzmin","orcid":null,"position":1,"is_corresponding":false},{"id":1557313,"name":"Viktoria O. Guskova","orcid":null,"position":2,"is_corresponding":false},{"id":430358,"name":"Denis V. Abramochkin","orcid":"0000-0001-5751-8853","position":3,"is_corresponding":false},{"id":1557310,"name":"Tatiana S. Filatova","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sodium current preserves electrical excitability in the heart of hibernating ground squirrel (Citellus undulatus)","abstract":"Hibernating mammals are capable of maintaining normal cardiac function at low temperatures. Excitability of cardiac myocytes crucially depends on the fast sodium current (I<sub>Na</sub>), which is decreased in hypothermia due to both depolarization of resting membrane potential and direct negative effect of low temperature. Therefore, I<sub>Na</sub> in hibernating mammals should have specific features allowing to maintain excitability of myocardium at low temperatures. The current-voltage dependence of I<sub>Na</sub>, its steady-state inactivation and activation and recovery from inactivation were studied in winter hibernating (WH) and summer active (SA) ground squirrels and in rats using whole-cell patch clamp at 10 °C and 20 °C. I<sub>Na</sub> peak amplitude and the parameters of steady-state activation and inactivation curves did not differ between SA and WH ground squirrels at both temperatures. However, at both temperatures strong positive shift of activation and inactivation curves by 5-12 mV was observed in both WH and SA ground squirrels if compared to rats. This peculiarity of cardiac I<sub>Na</sub> in ground squirrels helps to maintain excitability in conditions of depolarized resting membrane potential. The time course of I<sub>Na</sub> recovery from inactivation at 10 °C was faster in WH than in SA ground squirrels, which could ensure normal activation of myocardium during hibernation.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37207928","pmcid":null,"openalex_id":"https://openalex.org/W4376866198","authors":[],"funders":[{"funder_name":"Ministry of Science and Higher Education of the Russian Federation","grant_id":"122012100156–5","title":null},{"funder_name":"Ministry of Science and Higher Education of the Russian Federation","grant_id":"","title":null}],"total_grants":2,"fwci":0.5603,"citation_percentile":0.60964264,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1095643323000855?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1095643323000855?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cbpa.2023.111452","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37207928","host_type":"repository"}],"fields_of_study":["Ion channel regulation and function","Heart Rate Variability and Autonomic Control","Neural dynamics and brain function","Animals","Rats","Sodium","Heart","Myocardium","Mammals","Sciuridae","Hibernation"],"mesh_terms":["Animals","Heart","Hibernation","Mammals","Myocardium","Sciuridae","Sodium","Rats"],"keywords":["Ground squirrel","Hibernation (computing)","Depolarization","Membrane potential","Biophysics","Sodium","Chemistry","Hypothermia","Resting potential","Sodium channel","Internal medicine","Endocrinology","Biology","Medicine","Hibernation","Heart","Action potential","Patch-clamp","Ionic Current"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T04:51:11.370837Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}