{"doi":"10.1016/j.cbpa.2020.07.011","title":"A critical evaluation of probes for cysteine sulfenic acid","abstract":null,"journal":"Current Opinion in Chemical Biology","year":2021,"id":679254,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1774725,"name":"Justin M. Chalker","orcid":null,"position":1,"is_corresponding":false},{"id":1774723,"name":"Jasmine M.M. Pople","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A critical evaluation of probes for cysteine sulfenic acid","abstract":"Cysteine oxidation is important in cellular redox regulation, signaling, and biocatalysis. To understand the biological relevance of cysteine oxidation, it is desirable to identify the proteins involved, the site of the oxidized cysteine, and the relevant oxidation states. Because the thiol of cysteine can be converted to a wide range of oxidation states, mapping these oxidative modifications is challenging. The dynamic and reversible nature of many cysteine oxidation states compounds the difficulty in such proteomic analyses. In this review, we examine methods to detect cysteine sulfenic acid - a particularly challenging functional group to analyze because of its reactive nature. We focus on the selectivity of recently reported probes and discuss some challenges and opportunities in this field.","is_dataset_classified":null,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32866852","pmcid":null,"openalex_id":"https://openalex.org/W3082648488","authors":[],"funders":[{"funder_name":"Australian Research Council","grant_id":"DE150101863","title":"Discovery Early Career Researcher Award - Grant ID: DE150101863"},{"funder_name":"Australian Research Council","grant_id":"DP200100090","title":"Discovery Projects - Grant ID: DP200100090"},{"funder_name":"Flinders Medical Centre Foundation","grant_id":"","title":null}],"total_grants":3,"fwci":1.6286,"citation_percentile":0.81702057,"influential_citations":0,"citation_trend":[{"year":2021,"count":10},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2024,"count":6},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1367593120301071?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1367593120301071?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cbpa.2020.07.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32866852","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.cbpa.2020.07.011","host_type":""}],"fields_of_study":["Sulfur Compounds in Biology","Click Chemistry and Applications","Peptidase Inhibition and Analysis","0301 basic medicine","03 medical and health sciences","01 natural sciences","0104 chemical sciences"],"mesh_terms":["Cysteine","Humans","Oxidation-Reduction","Sulfenic Acids","Molecular Probes"],"keywords":["Sulfenic acid","Cysteine","Chemistry","Biochemistry","Thiol","Cysteine metabolism","Combinatorial chemistry","Computational biology","Enzyme","Biology","Oxidative stress","Cysteine Oxidation","Dimedone","Cysteine Sulfenic Acid","Sulfenamide","Sulfenome","Molecular Probes","Humans","Oxidation-Reduction","Sulfenic Acids"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T12:40:50.270320Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}