{"doi":"10.1016/j.cbpa.2010.04.019","title":"Accumulation of caveolin-3 protein is limited in damaged muscle in chicken muscular dystrophy","abstract":null,"journal":"Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology","year":2010,"id":671236,"datarank":0.4384731665253368,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.16970924614112853,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.16970924614112853,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1753545,"name":"Shinji Sasazaki","orcid":null,"position":1,"is_corresponding":false},{"id":1753546,"name":"Akira Fujiwara","orcid":null,"position":2,"is_corresponding":false},{"id":1753547,"name":"Nobutsune Ichihara","orcid":null,"position":3,"is_corresponding":false},{"id":1753548,"name":"Tateki Kikuchi","orcid":null,"position":4,"is_corresponding":false},{"id":1753549,"name":"Hideyuki Mannen","orcid":null,"position":5,"is_corresponding":false},{"id":1591326,"name":"Hirokazu Matsumoto","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Accumulation of caveolin-3 protein is limited in damaged muscle in chicken muscular dystrophy","abstract":"Members of the caveolin family are the main component of caveolae, and caveolin-3 is a muscle-specific protein. Caveolin-3 deficiency induces a muscular dystrophic phenotype, while its overexpression is also harmful to muscle cells. Increased caveolae were observed in chicken muscular dystrophy; however, the underlying mechanism causing the onset remains unclear. Therefore, the current study analyzes the expression of caveolin-3 and other caveola-related proteins in dystrophic chickens. Western blotting and semi-quantitative RT-PCR analysis revealed that (1) caveolin-3 is highly expressed in the damaged muscle of dystrophic chickens (7.12-fold); (2) the amount of caveolin-3 protein is regulated in posttranslational modification, since no significant increase is observed at the mRNA level (1.09-fold); and (3) the expression pattern of other caveola-related proteins is similar to that of caveolin-3. These results suggest that the accumulation of caveolin-3 protein may be associated with the causative process of chicken muscular dystrophy.","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20451648","pmcid":null,"openalex_id":"https://openalex.org/W2072550205","authors":[],"funders":[],"total_grants":0,"fwci":0.2473,"citation_percentile":0.53907188,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2020,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1095643310001492?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1095643310001492?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cbpa.2010.04.019","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20451648","host_type":"repository"}],"fields_of_study":["Caveolin-1 and cellular processes","Signaling Pathways in Disease","Peroxisome Proliferator-Activated Receptors","Animals","Caveolin 3","Chickens","Female","Male","Muscle, Skeletal","Muscular Dystrophies","Phenotype","Reverse Transcriptase Polymerase Chain Reaction"],"mesh_terms":["Animals","Chickens","Female","Male","Muscular Dystrophies","Phenotype","Muscle, Skeletal","Reverse Transcriptase Polymerase Chain Reaction","Caveolin 3"],"keywords":["Caveolae","Caveolin 3","Muscular dystrophy","Caveolin 1","Caveolin","Dysferlin","Biology","Blot","Cell biology","Phenotype","ITGA7","Myocyte","Messenger RNA","Dystrophy","Molecular biology","Genetics","Gene","Signal transduction"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T01:53:14.446411Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}