{"doi":"10.1016/j.carrev.2024.09.006","title":"Comparison of high-risk characteristics of non-culprit plaques in relation to plaque severity in acute coronary syndrome","abstract":null,"journal":"Cardiovascular Revascularization Medicine","year":2025,"id":625606,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1618051,"name":"Frans B. Mensink","orcid":null,"position":1,"is_corresponding":false},{"id":1618052,"name":"Jonathan Los","orcid":null,"position":2,"is_corresponding":false},{"id":1618053,"name":"Peter Damman","orcid":null,"position":3,"is_corresponding":false},{"id":1618054,"name":"Niels van Royen","orcid":null,"position":4,"is_corresponding":false},{"id":1618055,"name":"Mohamed A.H. Abdelhafez","orcid":null,"position":5,"is_corresponding":false},{"id":1618056,"name":"Hamdy Shams Eddin Mohamed","orcid":null,"position":6,"is_corresponding":false},{"id":1618057,"name":"Salwa R. Demitry","orcid":null,"position":7,"is_corresponding":false},{"id":1618058,"name":"Tim J.F. ten Cate","orcid":null,"position":8,"is_corresponding":false},{"id":1618059,"name":"Robert-Jan van Geuns","orcid":null,"position":9,"is_corresponding":false},{"id":1618049,"name":"Mohamed M. Reda Abdelaziz Morsy","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of high-risk characteristics of non-culprit plaques in relation to plaque severity in acute coronary syndrome","abstract":"Patients with acute coronary syndrome (ACS) have high event rates related to non-culprit (NC) lesions, therefore plaque composition of these lesions is of great interest. Although marginal atherosclerotic lesions were studied extensively, more significant lesions might have more high-risk characteristics. To compare differences in high-risk lesion characteristics between significant versus non-stenotic NC plaques in ACS and the discrepancies with chronic coronary syndrome (CCS) patients. Non-culprit vessels of 26 ACS patients with 26 angiographically significant lesions and 37 patients (17 ACS and 20 CCS) with 48 non-stenotic lesions were investigated with intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS). Overall, 74 segments of 30 mm length were analyzed in 1 mm intervals. External elastic lamina (EEM), plaque burden (PB), minimal luminal area (MLA), percent atheroma volume (PAV) and lipid core burden index maximum 4 mm (maxLCBI 4mm ) were determined for each segment. Cardiovascular risk factors were similar in all groups. PB was higher and MLA smaller in significant non-culprit ACS lesions vs non-stenotic lesions: PB 73.5% (IQR 68.7–78.5) vs 59.2 (IQR 49.6–71.5), p = 0.003, MLA 3.0 mm 2 (IQR 2.3–3.9) vs 4.0 mm 2 (IQR 2.8–4.7). MaxLCBI 4mm was similar 308.1 (±155.4) vs 287.8 (±165.7), p = 0.67. Among non-stenotic plaques, MaxLCBI 4mm was comparable between ACS and CCS patients, 275.7 (±151.5) in CCS patients vs 287.8 (±165.7) in ACS patients, p = 0.79. Although visually significant non-culprit lesions had a higher plaque burden compared to non-stenotic lesions, a significant relation between MaxLCBI 4mm and hemodynamic significance of the plaques couldn’t be established. • Intravascular ultrasound (IVUS) is helpful to show features of non-culprit lesions responsible for unanticipated events. • Lipid content of coronary plaques is measured by NIRS and represented by the lipid core burden index (LCBI) • Combination of plaques with high lipid content (MaxLCBI 4mm >400) and large plaque burden >70% were key features of vulnerable plaques that placed patients at especially substantial risk for future MACE.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39322479","pmcid":null,"openalex_id":"https://openalex.org/W4402564846","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.26055378,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.carrev.2024.09.006","host_type":"journal"},{"url":"https://doi.org/10.1016/j.carrev.2024.09.006","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1553838924006663?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1553838924006663?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39322479","host_type":"repository"},{"url":"https://hdl.handle.net/2066/320313","host_type":"repository"},{"url":"https://repository.ubn.ru.nl//bitstream/handle/2066/320313/320313.pdf","host_type":"repository"}],"fields_of_study":["Acute Myocardial Infarction Research","Coronary Interventions and Diagnostics","Cardiac Imaging and Diagnostics","Humans","Plaque, Atherosclerotic","Acute Coronary Syndrome","Male","Female","Middle Aged","Ultrasonography, Interventional","Aged","Severity of Illness Index","Coronary Vessels","Risk Assessment","Spectroscopy, Near-Infrared","Coronary Angiography","Coronary Artery Disease","Predictive Value of Tests","Risk Factors"],"mesh_terms":["Aged","Coronary Artery Disease","Coronary Vessels","Female","Humans","Male","Middle Aged","Predictive Value of Tests","Risk Factors","Severity of Illness Index","Coronary Angiography","Ultrasonography, Interventional","Risk Assessment","Spectroscopy, Near-Infrared","Acute Coronary Syndrome","Plaque, Atherosclerotic"],"keywords":["Medicine","Culprit","Acute coronary syndrome","Cardiology","Internal medicine","Vulnerable plaque","Myocardial infarction","Near infrared spectroscopy","Intravascular Imaging","Max Lipid Core Burden Index"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T07:15:48.207761Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}