{"doi":"10.1016/j.cardfail.2012.09.004","title":"A Global Transcriptome Analysis of a Dog Model of Congestive Heart Failure With the Human Genome as a Reference","abstract":null,"journal":"Journal of Cardiac Failure","year":2012,"id":671508,"datarank":0.6024657457939638,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.22972974832576368,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.22972974832576368,"corpus_percentile":67.9,"corpus_rank":4427,"citation_count":11,"citer_count":6,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1754325,"name":"Takehiro Matsumoto","orcid":null,"position":1,"is_corresponding":false},{"id":1754326,"name":"Atuyuki Wada","orcid":null,"position":2,"is_corresponding":false},{"id":1754327,"name":"Masafumi Suzaki","orcid":null,"position":3,"is_corresponding":false},{"id":1754328,"name":"Tokuhiro Chano","orcid":null,"position":4,"is_corresponding":false},{"id":1633543,"name":"Takahiro Isono","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Global Transcriptome Analysis of a Dog Model of Congestive Heart Failure With the Human Genome as a Reference","abstract":"<h4>Background</h4>The global molecular changes in cardiac tissue during congestive heart failure (CHF) have not been fully examined. Transcriptome analysis with the use of next-generation sequencers is a useful tool for elucidating the pathogenesis of CHF. Although there are some advantages in a dog CHF model, transcriptome analyses in dogs are limited by the relative lack of genomic information.<h4>Methods and results</h4>The transcriptome analysis of hearts from dogs with CHF was conducted with the use of a genome analyzer and the Casava software. The mRNA sequence reads showed alignments with ∼800 of 1,019 genes from the dog reference database. On the other hand, the reads aligned with ∼15,000 of the 21,407 genes in the hg19 human reference database. The correlation of expressed genes was extremely high (r = 0.93; P < .0001) between the dog and human databases. A pathway analysis using the hg19 reference revealed increased expression of p53 pathway-related (P < 10(-10)) and inflammatory interleukin-related (P < 10(-10)) genes in the CHF model.<h4>Conclusions</h4>The use of the human genome as a reference in global transcriptome analyses of dogs is a useful approach for investigating diseases such as CHF. Such an approach would also be useful for analyzing disease models in other experimental animals.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23141859","pmcid":null,"openalex_id":"https://openalex.org/W2166777687","authors":[],"funders":[],"total_grants":0,"fwci":0.5208,"citation_percentile":0.71795952,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2022,"count":2},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S1071916412012663?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S1071916412012663?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cardfail.2012.09.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23141859","host_type":"repository"}],"fields_of_study":["Cardiac Fibrosis and Remodeling","Gene expression and cancer classification","Molecular Biology Techniques and Applications","Amino Acid Sequence","Animals","Databases, Genetic","Disease Models, Animal","Dogs","Gene Expression Profiling","Genome, Human","Heart Failure","Humans","Molecular Sequence Data","Species Specificity"],"mesh_terms":["Amino Acid Sequence","Animals","Disease Models, Animal","Dogs","Heart Failure","Humans","Molecular Sequence Data","Species Specificity","Genome, Human","Gene Expression Profiling","Databases, Genetic"],"keywords":["Transcriptome","Heart failure","Reference genome","Genome","Computational biology","Medicine","Gene","Reference genes","Bioinformatics","Biology","Genetics","Gene expression","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T03:05:46.874847Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}