{"doi":"10.1016/j.carbpol.2019.115643","title":"Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development","abstract":null,"journal":"Carbohydrate Polymers","year":2020,"id":601531,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164791,"name":"Meng Qiao","orcid":null,"position":1,"is_corresponding":false},{"id":799960,"name":"Xing Zhang","orcid":"0000-0003-4315-6980","position":2,"is_corresponding":false},{"id":286697,"name":"Robert J. Linhardt","orcid":"0000-0003-2219-5833","position":3,"is_corresponding":false},{"id":299564,"name":"Lei Lin","orcid":"0000-0002-4077-4380","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development","abstract":"Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, inflammation, immune response, tumor metastasis and in viral/bacterial/parasitic infections. However, it is difficult to obtain these naturally occurring glycoconjugates as they are often heterogeneous compositions, which causes batch-to-batch variability of structure and activity often leading an incomplete understanding of their mechanism of action. Thus, the efficient preparation of synthetic glycoconjugates, possessing well-defined compositions and reproducible biological properties is highly desirable. In the present review, we summarize the advances in site-selective approaches for glycoconjugate synthesis and, in particular, the preparation of polysaccharide vaccines.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31887910","pmcid":null,"openalex_id":"https://openalex.org/W2990589822","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"DK111958","title":null},{"funder_name":"Shandong University","grant_id":"2019CCG03","title":null},{"funder_name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","grant_id":"19KJB150012","title":null},{"funder_name":"Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions","grant_id":"19KJB150013","title":null}],"total_grants":4,"fwci":1.8089,"citation_percentile":0.84323453,"influential_citations":0,"citation_trend":[{"year":2020,"count":3},{"year":2021,"count":9},{"year":2022,"count":6},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0144861719313116?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0144861719313116?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.carbpol.2019.115643","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31887910","host_type":"repository"}],"fields_of_study":["Carbohydrate Chemistry and Synthesis","Glycosylation and Glycoproteins Research","Click Chemistry and Applications"],"mesh_terms":[],"keywords":["Glycoconjugate","Glycolipid","Glycoprotein","Polysaccharide","Biochemistry","Chemistry","Immune system","Biology","Immunology","Carbohydrates","Glycoconjugates","Polysaccharide Vaccine","Site-selective Reactions"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T16:38:24.478966Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}