{"doi":"10.1016/j.carbpol.2016.09.038","title":"Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release","abstract":null,"journal":"Carbohydrate Polymers","year":2017,"id":638349,"datarank":0.5289540786924243,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"self_citation_contribution":0.5289540786924243,"citation_network_contribution":0.0,"self_endowment_contribution":0.5289540786924243,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1352719,"name":"Hongqin Yang","orcid":"0000-0002-7794-5921","position":1,"is_corresponding":false},{"id":1447267,"name":"Bin Tang","orcid":"0000-0001-6096-0837","position":2,"is_corresponding":false},{"id":495234,"name":"Di Wu","orcid":"0000-0002-3238-6388","position":3,"is_corresponding":false},{"id":1657921,"name":"Qiaohong Du","orcid":null,"position":4,"is_corresponding":false},{"id":1303521,"name":"Kailin Xu","orcid":"0000-0003-1375-1084","position":5,"is_corresponding":false},{"id":431029,"name":"Hui Li","orcid":"0000-0002-1973-3074","position":6,"is_corresponding":false},{"id":1657920,"name":"Peixiao Tang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dimethyl-β-cyclodextrin/salazosulfapyridine inclusion complex-loaded chitosan nanoparticles for sustained release","abstract":"This study aimed to investigate a novel delivery system for salazosulfapyridine (SASP) through encapsulation in 2,6-dimethyl-β-cyclodextrin (DMβCD) and further incorporation in chitosan (CS) to form nanoparticles (NPs). The inclusion complex of SASP and DMβCD was prepared at 1:1 host-guest stoichiometry based on Job's plot and then characterized through various analytical techniques. Then, the DMβCD/SASP inclusion complex was incorporated in CS to form DMβCD/SASP/CS NPs. The loading efficiency of SASP in the DMβCD/SASP/CS NPs was significantly higher than that of the SASP/CS NPs. A positive zeta potential of +35.4mV was also observed in the DMβCD/SASP/CS NPs with an average size of 90nm. SASP exhibited a sustained release after the DMβCD/SASP/CS NPs were formed. The toxicity of the NPs to LO2 cells was lower than that of free SASP. Therefore, the CD inclusion complex-loaded CS NPs can be applied to deliver hydrophobic drugs.","is_dataset_classified":null,"base_score":3.5263605246161616,"endowment":3.5263605246161616,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27842816","pmcid":null,"openalex_id":"https://openalex.org/W2518963878","authors":[],"funders":[{"funder_name":"Applied Basic Research Project of Sichuan Province","grant_id":"2014JY0042","title":null},{"funder_name":"National Development and Reform Commission and Education of China","grant_id":"2014BW011","title":null},{"funder_name":"Large-scale Science Instrument Shareable Platform Construction of Sichuan Province","grant_id":"2015JCPT0005-15010102","title":null}],"total_grants":3,"fwci":1.7711,"citation_percentile":0.82673929,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":6},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2021,"count":6},{"year":2022,"count":5},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S014486171631092X?httpAccept=text/plain","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S014486171631092X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.carbpol.2016.09.038","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27842816","host_type":"repository"}],"fields_of_study":["Advanced Drug Delivery Systems","Drug Solubulity and Delivery Systems","Nanoparticle-Based Drug Delivery","Chitosan","Delayed-Action Preparations","Drug Carriers","Nanoparticles","Particle Size","Sulfasalazine","beta-Cyclodextrins"],"mesh_terms":["Delayed-Action Preparations","Drug Carriers","Particle Size","Sulfasalazine","beta-Cyclodextrins","Chitosan","Nanoparticles"],"keywords":["Cyclodextrin","Chitosan","Chemistry","Zeta potential","Beta-Cyclodextrins","Inclusion compound","Stoichiometry","Nuclear chemistry","Nanoparticle","Nanotechnology","Chromatography","Organic chemistry","Materials science","Nanoparticles","sustained release","2,6-Dimethyl-β-cyclodextrin","Chitosan (Pubchem Cid: 71853)","2,6-Dimethyl-β-cyclodextrin (Pubchem Cid: 10171019)","Salazosufapyridine","Salazosulfapyridine (Pubchem Cid: 5359476)"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T20:32:43.082008Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}