{"doi":"10.1016/j.canlet.2025.217813","title":"CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation","abstract":null,"journal":"Cancer Letters","year":2025,"id":622043,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1606591,"name":"Zidan Zhao","orcid":null,"position":1,"is_corresponding":false},{"id":1606593,"name":"Shangbo Zhou","orcid":null,"position":2,"is_corresponding":false},{"id":1606595,"name":"Ziwen Zhou","orcid":null,"position":3,"is_corresponding":false},{"id":1606596,"name":"Zhangsen Huang","orcid":null,"position":4,"is_corresponding":false},{"id":154690,"name":"Zhijun Zhou","orcid":null,"position":5,"is_corresponding":false},{"id":341736,"name":"Changhua Zhang","orcid":"0000-0003-4358-4096","position":6,"is_corresponding":false},{"id":1606589,"name":"Yuntao Shi","orcid":"0009-0002-5215-8195","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"CHD4 drives gastric cancer metastasis via MYH9/GSK3β/β-catenin axis and WNT/EMT pathway activation","abstract":"Gastric cancer (GC) metastasis remains a significant cause of cancer-related mortality, yet the molecular mechanisms underlying this process have not been fully elucidated. CHD4, a chromatin remodeling factor, has been associated with oncogenic processes, but its precise role in GC metastasis has not been defined. In this study, we identify CHD4 as a critical regulator of GC metastasis through the MYH9/GSK3β/β-catenin axis and the activation of the WNT pathway and epithelial-mesenchymal transition (EMT). Clinically, CHD4 was significantly overexpressed in GC tissues and strongly correlated with advanced disease stages and poor prognosis. Mechanistically, CHD4 interacted with MYH9 via its ATPase domain and promoted the nuclear-to-cytoplasmic translocation of MYH9, thereby enabling MYH9 to orchestrate inhibitory phosphorylation and ubiquitination-dependent degradation of GSK3β. This, in turn, stabilized β-catenin, leading to its nuclear accumulation and activation of downstream WNT target genes, such as Cyclin D1, along with the induction of EMT. Functionally, suppression of CHD4 expression inhibited GC cell migration, invasion, and metastasis in vivo, while MYH9 restoration reversed these effects. Collectively, these findings establish CHD4 as a key regulator of GC metastasis through the MYH9/GSK3β/β-catenin axis and underscore its potential as a therapeutic target for inhibiting GC progression.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40480417","pmcid":null,"openalex_id":"https://openalex.org/W4411024479","authors":[],"funders":[{"funder_name":"Basic and Applied Basic Research Foundation of Guangdong Province","grant_id":"2019A1515110547","title":null},{"funder_name":"Sanming Project of Medicine in Shenzen Municipality","grant_id":"SZSM201911010","title":null}],"total_grants":2,"fwci":4.4692,"citation_percentile":0.95267172,"influential_citations":0,"citation_trend":[{"year":2025,"count":3},{"year":2026,"count":8}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304383525003805?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304383525003805?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.canlet.2025.217813","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40480417","host_type":"repository"}],"fields_of_study":["Cancer-related gene regulation","Wnt/β-catenin signaling in development and cancer","Epigenetics and DNA Methylation","Humans","Stomach Neoplasms","Epithelial-Mesenchymal Transition","Myosin Heavy Chains","beta Catenin","Glycogen Synthase Kinase 3 beta","Wnt Signaling Pathway","Animals","Cell Line, Tumor","Cell Movement","Female","DNA Helicases","Male","Mice, Nude","Gene Expression Regulation, Neoplastic","Neoplasm Metastasis","Mice","Neoplasm Invasiveness","Mice, Inbred BALB C","Middle Aged","Mi-2 Nucleosome Remodeling and Deacetylase Complex"],"mesh_terms":["Glycogen Synthase Kinase 3 beta","Animals","Cell Movement","DNA Helicases","Female","Humans","Male","Mice, Inbred BALB C","Mice, Nude","Middle Aged","Neoplasm Invasiveness","Neoplasm Metastasis","Stomach Neoplasms","Gene Expression Regulation, Neoplastic","Myosin Heavy Chains","Cell Line, Tumor","beta Catenin","Mice","Mi-2 Nucleosome Remodeling and Deacetylase Complex","Epithelial-Mesenchymal Transition","Wnt Signaling Pathway"],"keywords":["Wnt signaling pathway","Catenin","Metastasis","Cancer research","Cancer","Beta-catenin","Chemistry","Biology","Medicine","Cell biology","Signal transduction","Internal medicine","Tumor metastasis","Wnt/β-catenin Signaling","Nuclear-cytoplasmic Trafficking","Chd4-myh9 Axis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T17:58:23.364359Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}