{"doi":"10.1016/j.canlet.2019.05.038","title":"Interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma by promoting interferon response","abstract":null,"journal":"Cancer Letters","year":2019,"id":634953,"datarank":0.5955437870328184,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":0.0,"self_endowment_contribution":0.5955437870328184,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1647055,"name":"Jiagen Li","orcid":null,"position":1,"is_corresponding":false},{"id":618669,"name":"Yuan Li","orcid":"0000-0001-9809-9894","position":2,"is_corresponding":false},{"id":181043,"name":"Zhiliang Lu","orcid":null,"position":3,"is_corresponding":false},{"id":1647058,"name":"Yun Che","orcid":null,"position":4,"is_corresponding":false},{"id":1647060,"name":"Shuangshuang Mao","orcid":null,"position":5,"is_corresponding":false},{"id":1647061,"name":"Yuanyuan Lei","orcid":null,"position":6,"is_corresponding":false},{"id":1647062,"name":"Ruochuan Zang","orcid":null,"position":7,"is_corresponding":false},{"id":1647063,"name":"Sufei Zheng","orcid":null,"position":8,"is_corresponding":false},{"id":1647064,"name":"Chengming Liu","orcid":null,"position":9,"is_corresponding":false},{"id":50275,"name":"Xinfeng Wang","orcid":"0000-0002-5656-1750","position":10,"is_corresponding":false},{"id":407579,"name":"Ning Li","orcid":"0009-0000-5454-3084","position":11,"is_corresponding":false},{"id":50276,"name":"Nan Sun","orcid":"0000-0001-7583-9802","position":12,"is_corresponding":false},{"id":34794,"name":"Jie He","orcid":"0000-0002-0285-5403","position":13,"is_corresponding":false},{"id":1647054,"name":"Jianbing Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma by promoting interferon response","abstract":"Interferons (IFNs) play crucial roles in the development and treatment of cancer. Long non-coding RNAs (lncRNAs) are emerging molecules involved in cancer progression. Here, we identified and characterized an IFN-inducible nuclear lncRNA IRF1-AS (Interferon Regulatory Factor 1 Antisense RNA) which was positively correlated with IRF1 expression. IFNs upregulate IRF1-AS via the JAK-STAT pathway. Knockdown and overexpression of IRF1-AS revealed that IRF1-AS inhibits oesophageal squamous cell carcinoma (ESCC) proliferation and promotes apoptosis in vitro and in vivo. Mechanistically, IRF1-AS activates IRF1 (Interferon Regulatory Factor 1) transcription through interacting with ILF3 (Interleukin Enhancer Binding Factor 3) and DHX9 (DExH-Box Helicase 9). In turn, IRF1 binds to the IRF1-AS promoter directly and activates IRF1-AS transcription. Global analysis of IRF1-AS-regulated genes indicated that IRF1-AS activates the IFN response in vitro and in vivo. IRF1 knockdown in IRF1-AS-overexpressing cells abolished the antiproliferative effect and activation of the IFN response. Furthermore, IRF1-AS was downregulated in ESCC tissues, and low expression correlated with poor prognosis. In conclusion, the interferon-inducible lncRNA IRF1-AS represses esophageal squamous cell carcinoma progression by promoting interferon response through a positive regulatory loop with IRF1.","is_dataset_classified":null,"base_score":3.970291913552122,"endowment":3.970291913552122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31173852","pmcid":null,"openalex_id":"https://openalex.org/W2948164576","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"81802299","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81502514","title":null},{"funder_name":"Central Universities","grant_id":"3332018070","title":null},{"funder_name":"CIFMS","grant_id":"2016-I2M-1-001","title":null},{"funder_name":"CIFMS","grant_id":"2017-I2M-1-005","title":null},{"funder_name":"National Key Basic Research Development Plan","grant_id":"2018YFC1312105","title":null}],"total_grants":6,"fwci":1.9768,"citation_percentile":0.8632355,"influential_citations":0,"citation_trend":[{"year":2019,"count":2},{"year":2020,"count":7},{"year":2021,"count":10},{"year":2022,"count":11},{"year":2023,"count":8},{"year":2024,"count":5},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.sciencedirect.com/science/article/pii/S0304383519303398/pdf","host_type":"journal"},{"url":"https://www.sciencedirect.com/science/article/pii/S0304383519303398/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304383519303398?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304383519303398?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.canlet.2019.05.038","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31173852","host_type":"repository"}],"fields_of_study":["Cancer-related molecular mechanisms research","RNA modifications and cancer","Mycobacterium research and diagnosis"],"mesh_terms":["Esophageal Squamous Cell Carcinoma","Animals","Esophageal Neoplasms","Humans","Interferon-gamma","Mice, Inbred BALB C","Mice, Nude","Transcriptional Activation","RNA, Antisense","Interferon-beta","Apoptosis","Xenograft Model Antitumor Assays","Cell Proliferation","Interferon Regulatory Factor-1","Mice","RNA, Long Noncoding"],"keywords":["IRF1","Gene knockdown","Biology","Cancer research","Interferon regulatory factors","Interferon","IRF8","Cell biology","Transcription factor","Immunology","Cell culture","Gene","Biochemistry","Genetics","esophageal squamous cell carcinoma","Long Non-coding Rna","Irf1-as"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:25:00.368793Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}