{"doi":"10.1016/j.canlet.2018.12.006","title":"HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer","abstract":null,"journal":"Cancer Letters","year":2019,"id":593363,"datarank":1.1598707855079158,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.6711563048046935,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.6711563048046935,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":25,"citers_with_citation_signal":21,"citers_with_endowment":21,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1252871,"name":"Kyung Hee Jung","orcid":"0000-0002-1291-0461","position":1,"is_corresponding":false},{"id":1317279,"name":"Soo Jung Kim","orcid":"0000-0002-5140-1432","position":2,"is_corresponding":false},{"id":1518633,"name":"Young-Chan Yoon","orcid":null,"position":3,"is_corresponding":false},{"id":1518634,"name":"Hong Hua Yan","orcid":null,"position":4,"is_corresponding":false},{"id":1518635,"name":"Zhenghuan Fang","orcid":null,"position":5,"is_corresponding":false},{"id":909990,"name":"Ji Eun Lee","orcid":"0000-0002-4898-741X","position":6,"is_corresponding":false},{"id":1518636,"name":"Joo Han Lim","orcid":null,"position":7,"is_corresponding":false},{"id":1518637,"name":"Shinmee Mah","orcid":null,"position":8,"is_corresponding":false},{"id":930543,"name":"Sungwoo Hong","orcid":null,"position":9,"is_corresponding":false},{"id":1518638,"name":"You-Sun Kim","orcid":null,"position":10,"is_corresponding":false},{"id":1518639,"name":"Soon-Sun Hong","orcid":null,"position":11,"is_corresponding":false},{"id":1518632,"name":"Jung Hee Park","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer","abstract":"Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting kinase 3 (RIP3). Recently, necroptosis has gained attention as a novel alternative therapy to target cancer cells. In this study, we screened several chemotherapeutics used in preclinical and clinical studies, and identified a drug HS-173 that induces RIP3-mediated necroptosis. HS-173 decreased the cell survival in a dose-dependent manner in RIP3-expressing lung cancer cells, compared to the cells lacking RIP3. Also, the cell death induced by HS-173 was rescued by specific necroptosis inhibitors such as necrostatin-1 and dabrafenib. Additionally, HS-173 increased the phosphorylation of RIP3 and MLKL, which was decreased by necroptosis inhibitors, indicating that HS-173 activates RIP3/MLKL signaling in lung cancer cells. HS-173 increased the necroptotic events, as observed by the increased levels of HMGB1 and necroptotic morphological features. Furthermore, HS-173 inhibited the tumor growth by stimulation of necroptosis in mouse xenograft models. Our findings offer new insights into the role of HS-173 in inducing necroptosis by enhancing RIP3 expression and activating the RIP3/MLKL signaling pathway in lung cancer cells.","is_dataset_classified":null,"base_score":3.258096538021482,"endowment":3.258096538021482,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30583075","pmcid":null,"openalex_id":"https://openalex.org/W2906334526","authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2018R1A2A1A05077263","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2014M3C1A3051476","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2014009392","title":null},{"funder_name":"Institute for Basic Science","grant_id":"IBS-R010-G1","title":null},{"funder_name":"Korea Health Technology R&D Project","grant_id":"HI15C0554","title":null},{"funder_name":"Ministry of Health and Welfare","grant_id":"","title":null}],"total_grants":6,"fwci":0.4944,"citation_percentile":0.62954921,"influential_citations":0,"citation_trend":[{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":6},{"year":2023,"count":6},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304383518307213?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304383518307213?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.canlet.2018.12.006","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30583075","host_type":"repository"}],"fields_of_study":["Cell death mechanisms and regulation","Cancer-related Molecular Pathways","Nuclear Structure and Function","Animals","Apoptosis","Cell Proliferation","Gene Expression Regulation, Neoplastic","Humans","Lung Neoplasms","Male","Mice","Mice, Inbred BALB C","Mice, Nude","Necrosis","Phosphorylation","Pyridines","Reactive Oxygen Species","Receptor-Interacting Protein Serine-Threonine Kinases","Signal Transduction","Sulfonamides","Tumor Cells, Cultured","Xenograft Model Antitumor Assays"],"mesh_terms":["Animals","Humans","Lung Neoplasms","Male","Mice, Inbred BALB C","Mice, Nude","Necrosis","Phosphorylation","Pyridines","Sulfonamides","Tumor Cells, Cultured","Signal Transduction","Gene Expression Regulation, Neoplastic","Apoptosis","Reactive Oxygen Species","Xenograft Model Antitumor Assays","Cell Proliferation","Mice","Receptor-Interacting Protein Serine-Threonine Kinases"],"keywords":["Necroptosis","Programmed cell death","Cancer research","Cancer cell","Biology","Cancer","Kinase","Signal transduction","Cell biology","Apoptosis","Biochemistry","Lung cancer","Mlkl","Rip3","Hs-173"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T01:19:06.552074Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}