{"doi":"10.1016/j.canlet.2009.01.007","title":"Id-1 expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen receptor","abstract":null,"journal":"Cancer Letters","year":2009,"id":602268,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":313923,"name":"Yinghao Sun","orcid":"0000-0002-7603-0965","position":1,"is_corresponding":false},{"id":1544511,"name":"Gusheng Tang","orcid":null,"position":2,"is_corresponding":false},{"id":1544512,"name":"Chuanliang Xu","orcid":null,"position":3,"is_corresponding":false},{"id":1544513,"name":"Linhui Wang","orcid":"0000-0002-6070-1832","position":4,"is_corresponding":false},{"id":1544514,"name":"Yuxi Zhang","orcid":null,"position":5,"is_corresponding":false},{"id":1544515,"name":"Jiatao Ji","orcid":null,"position":6,"is_corresponding":false},{"id":384653,"name":"Bin Xu","orcid":"0000-0002-1294-4506","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Id-1 expression in androgen-dependent prostate cancer is negatively regulated by androgen through androgen receptor","abstract":"This study discovered that Id-1 expression in androgen-dependent prostate cancer decreased immediately after androgen deprivation but increased after longer androgen deprivation both in vivo and in vitro. Id-1 expression in androgen-independent LNCaP cells was about 6 fold as that in their parental cells. As was the case with LNCaP cells, when androgen receptor (AR) was introduced into AR-negative PC-3 cells, dihydrotestosterone inhibited while flutamide increased Id-1 expression. Thus, Id-1 expression in androgen-dependent prostate cancer was negatively regulated by androgen in a receptor-dependent way. The re-increased Id-1 might partially contribute to the emergence of androgen-independent prostate cancer after longer androgen deprivation therapy.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19201527","pmcid":null,"openalex_id":"https://openalex.org/W2104364640","authors":[],"funders":[],"total_grants":0,"fwci":1.5987,"citation_percentile":0.84323267,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2018,"count":2}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0304383509000305?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0304383509000305?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.canlet.2009.01.007","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19201527","host_type":"repository"}],"fields_of_study":["Prostate Cancer Treatment and Research","Cancer-related gene regulation","Prostate Cancer Diagnosis and Treatment"],"mesh_terms":["Androgens","Humans","Male","Neoplasms, Hormone-Dependent","Prostatic Neoplasms","Receptors, Androgen","RNA, Messenger","Dihydrotestosterone","Cell Line, Tumor","Inhibitor of Differentiation Protein 1"],"keywords":["Androgen receptor","LNCaP","Prostate cancer","Flutamide","Androgen","Dihydrotestosterone","Endocrinology","Internal medicine","Cancer research","Prostate","Antiandrogen","Androgen deprivation therapy","Biology","Medicine","Cancer","Hormone"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T18:52:22.964237Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}