{"doi":"10.1016/j.brs.2024.08.002","title":"Electrographic seizures during low-current thalamic deep brain stimulation in mice","abstract":"BACKGROUND: Deep brain stimulation of the central thalamus (CT-DBS) has potential for modulating states of consciousness, but it can also trigger electrographic seizures, including poly-spike-wave trains (PSWT). OBJECTIVES: To report the probability of inducing PSWTs during CT-DBS in awake, freely-moving mice. METHODS: Mice were implanted with electrodes to deliver unilateral and bilateral CT-DBS at different frequencies while recording electroencephalogram (EEG). We titrated stimulation current by gradually increasing it at each frequency until a PSWT appeared. Subsequent stimulations to test arousal modulation were performed at the current one step below the current that caused a PSWT during titration. RESULTS: In 2.21% of the test stimulations (10 out of 12 mice), CT-DBS caused PSWTs at currents lower than the titrated current, including currents as low as 20 μA. CONCLUSION: Our study found a small but significant probability of inducing PSWTs even after titration and at relatively low currents. EEG should be closely monitored for electrographic seizures when performing CT-DBS in both research and clinical settings.","journal":"Brain stimulation","year":2024,"id":473823,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1309731,"name":"Isabella Dalla Betta","orcid":"0000-0002-5715-9878","position":1,"is_corresponding":false},{"id":658013,"name":"John Tauber","orcid":"0000-0001-5453-046X","position":2,"is_corresponding":false},{"id":1309732,"name":"David R. Schreier","orcid":"0000-0001-6088-2015","position":3,"is_corresponding":false},{"id":494467,"name":"Emily P. Stephen","orcid":"0000-0003-1978-9622","position":4,"is_corresponding":false},{"id":305061,"name":"Matthew Wilson","orcid":"0000-0001-7149-3584","position":5,"is_corresponding":false},{"id":343788,"name":"Emery N. Brown","orcid":"0000-0003-2668-7819","position":6,"is_corresponding":false},{"id":1309730,"name":"Francisco Flores","orcid":"0000-0002-8974-9717","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:06:04.967429Z","pmid":"39134207","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}