{"doi":"10.1016/j.brs.2023.07.039","title":"Retrospective comparison of response rates in extended rTMS courses between age groups","abstract":"Background: In this retrospective analysis of naturalistic clinical data, response rates were assessed for patients diagnosed with MDD (N=166, nmales=55), who received >36 sessions of an acute course of rTMS, in an effort to increase response. Methods: This study analyzed PHQ-9 scores collected at treatment #36 and the final treatment session of the extended acute course of rTMS, in comparison to baseline. Further analysis compared patients ages 12-22 years (nyounger=48, Mage=18.42, SDage=2.36) with those 23-55 years old (Mage=39.00, SDage=9.64). Patients received bilateral rTMS (range 40-72, M=53.33, SD=8.14) with 1 Hz delivered to the right dorsolateral prefrontal cortex (dlPFC) for 360 pulses, followed by left dlPFC stimulation at 20 Hz for 1200 pulses. Results: Patients overall reported a 50.56% reduction in depression symptoms after the extended treatment sessions. The elder cohort reported 40.65% reduction in symptoms at session #36, and 51.30% reduction at the end of their extended treatment course (M=8.61, SD=5.76). In comparison, the younger cohort reported a 36.03% reduction in symptoms at session #36, and 48.69% reduction at the end of their extended treatment course (M=8.83, S=6.60). Conclusions: While the severity of baseline symptoms were more severe in the younger patients (PHQ-9baseline=17.13) than the elder (PHQ-9baseline=15.75), the lack of plateaued response seen in the adolescents and young adults indicates a possible need for longer treatment courses to achieve the same response. Conflict of Interest: None Funding: Patients who were already seeking TMS treatment were financially responsible (private payment/insurance coverage) for their acute course of TMS Therapy. Extended treatment course sessions may have been covered by insurance, by Salience (a private clinical practice) as part of another study, and/or privately paid for by the patient. Disclosures: None","journal":"Brain stimulation","year":2023,"id":410675,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7859,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1190946,"name":"Victoria Middleton","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:21:35.071397Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}