{"doi":"10.1016/j.brs.2021.10.249","title":"Relationship between dose and duration of treatment response in severely treatment-resistant depression patients treated with accelerated intermittent theta bust stimulation","abstract":"weeks of taVNS treatment.These data consist of 9 responders to taVNS treatment and 11 non-responders.One responder and 6 non-responders were infants of diabetic mothers (IDM).Logistic regression and paired ttests modeled response to treatment and WM diffusion changes, respectively.Multiple comparison correction was not performed for these exploratory analyses.Results: Logistic regression found pre-treatment mean kurtosis in the cortical spinal tract left (p ¼ 0.0280) and right (p ¼ 0.0273) predicted response to treatment while adjusting for IDM (p ¼ 0.0251).Following taVNS, fractional anisotropy in the right superior longitudinal fasciculus (p ¼ 0.050) and radial kurtosis in the right lower cortical spinal tract (p ¼ 0.044), near the cerebellar peduncle, increased more per week in responders compared to non-responders.Conclusions: taVNS affects measures of microstructural integrity and neural plasticity in specific WM tracts differently depending on whether infants attained full oral feeds or received a G-tube.WM assessment with sensitive kurtosis imaging could be both a valuable means of assessing microstructural changes attributable to taVNS treatment and a biomarker for predicting response to treatment while taking IDM status into account.","journal":"Brain stimulation","year":2021,"id":227756,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.872,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":810246,"name":"Andrew Geoly","orcid":"0000-0002-3483-026X","position":1,"is_corresponding":false},{"id":304031,"name":"Gregory L. Sahlem","orcid":"0000-0002-7225-3109","position":2,"is_corresponding":false},{"id":95860,"name":"Nolan Williams","orcid":"0000-0003-4368-3203","position":3,"is_corresponding":false},{"id":374838,"name":"Ian H. Kratter","orcid":"0000-0001-9122-4525","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:54:46.312854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}