{"doi":"10.1016/j.brainres.2022.148097","title":"Cerebral metabolic rate of oxygen (CMRO2) changes measured with simultaneous tDCS-MRI in healthy adults","abstract":"BACKGROUND: Transcranial direct current stimulation (tDCS) is a safe and well-tolerated noninvasive technique used for cortical excitability modulation. tDCS has been extensively investigated for its clinical applications; however further understanding of its underlying in-vivo physiological mechanisms remains a fundamental focus of current research. OBJECTIVES: ) using simultaneous MRI in healthy adults to provide a reference frame for its neurobiological mechanisms. METHODS: at three time points: pre-, during- and post- 15 minutes of 2.0 mA tDCS on left anodal dorsolateral prefrontal cortex. RESULTS: significantly increased by 5.9 % during-tDCS (175.68 ± 30.78 µmol/100g/min) compared to pre-tDCS (165.84 ± 25.32 µmol/100g/min; p = 0.0015), maintaining increased levels in post-tDCS (176.86 ± 28.58 µmol/100g/min). CONCLUSIONS: changes due to tDCS in healthy adults that may be incorporated in clinical studies to evaluate its therapeutic potential.","journal":"Brain Research","year":2022,"id":260229,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":913408,"name":"Lillian Walton Masters","orcid":"0000-0002-2743-412X","position":1,"is_corresponding":false},{"id":703677,"name":"Giuseppina Pilloni","orcid":"0000-0001-6226-5627","position":2,"is_corresponding":false},{"id":913409,"name":"Peidong He","orcid":"0000-0002-8074-9630","position":3,"is_corresponding":false},{"id":289236,"name":"Lauren Krupp","orcid":"0000-0001-7003-807X","position":4,"is_corresponding":false},{"id":414353,"name":"Abhishek Datta","orcid":"0000-0002-6778-8125","position":5,"is_corresponding":false},{"id":106035,"name":"Marom Bikson","orcid":"0000-0002-0493-8333","position":6,"is_corresponding":false},{"id":268057,"name":"Leigh Charvet","orcid":"0000-0003-4429-9713","position":7,"is_corresponding":false},{"id":397407,"name":"Yulin Ge","orcid":"0000-0002-2320-6031","position":8,"is_corresponding":false},{"id":663837,"name":"Marco Muccio","orcid":"0000-0003-1559-7113","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T00:26:03.189798Z","pmid":"36150457","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}