{"doi":"10.1016/j.brainres.2016.10.008","title":"β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy","abstract":null,"journal":"Brain Research","year":2016,"id":681589,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1022342,"name":"Liping Huang","orcid":"0000-0002-0945-8988","position":1,"is_corresponding":false},{"id":1780818,"name":"Baile Ning","orcid":null,"position":2,"is_corresponding":false},{"id":1154343,"name":"Nanbu Wang","orcid":"0000-0002-7119-8304","position":3,"is_corresponding":false},{"id":1236784,"name":"Qinxin Zhang","orcid":"0000-0003-3819-5504","position":4,"is_corresponding":false},{"id":831828,"name":"Caixia Zhu","orcid":null,"position":5,"is_corresponding":false},{"id":1780819,"name":"Yongqi Fang","orcid":null,"position":6,"is_corresponding":false},{"id":1780816,"name":"Minzhen Deng","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"β-asarone improves learning and memory and reduces Acetyl Cholinesterase and Beta-amyloid 42 levels in APP/PS1 transgenic mice by regulating Beclin-1-dependent autophagy","abstract":"Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly, and studies have suggested that β-asarone has pharmacological effects on beta-amyloid (Aβ) injected in the rat hippocampus. However, the effect of β-asarone on autophagy in the APP/PS1 transgenic mouse is unreported. APP/PS1 transgenic mice were randomly divided into six groups (n=10/group): an untreated group, an Aricept-treated group, a 3-MA-treated group, a rapamycin-treated group, an LY294002-treated group, a β-asarone-treated group. The control group consisted of wild-type C57BL/6 mice. All treatments were administered to the mice for 30 days. Spatial learning and memory were assessed by water maze, passive avoidance, and step-down tests. AChE and Aβ<sub>42</sub> levels in the hippocampus were determined by ELISA. p-Akt, p-mTOR, and LC3B expression were detected by flow cytometry. The expression of p-Akt, p-mTOR, Beclin-1, and p62 proteins was assessed by western blot. Changes in autophagy were viewed using a transmission electron microscope. APP and Beclin-1 mRNA levels were measured by Real-Time PCR. The learning and memory of APP/PS1 transgenic mice were improved significantly after β-asarone treatment compared with the untreated group. In addition, β-asarone treatment reduced AChE and Aβ<sub>42</sub> levels, increased p-mTOR and p62 expression, decreased p-Akt, Beclin-1, and LC3B expression, decreased the number of autophagosomes and reduced APP mRNA and Beclin-1 mRNA levels compared with the untreated group. That is, β-asarone treatment can improve the learning and memory abilities of APP/PS1 transgenic mouse by inhibiting Beclin-1-dependent autophagy via the PI3K/Akt/mTOR pathway.","is_dataset_classified":null,"base_score":4.219507705176107,"endowment":4.219507705176107,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27737765","pmcid":null,"openalex_id":"https://openalex.org/W2531585213","authors":[],"funders":[{"funder_name":"Guangdong Province Academy of Traditional Chinese Medicine","grant_id":"2012A032400006","title":null},{"funder_name":"Guangzhou University of Chinese Medicine","grant_id":"A1-AFD018161Z01024","title":null},{"funder_name":"Scientific Research Cultivating Fund of Hannan Medical University","grant_id":"HY2015-01","title":null},{"funder_name":"Science and Technology Association of Hainan Province in China","grant_id":"HAST201635","title":null},{"funder_name":"Hainan Natural Science Foundation of China","grant_id":"20168266","title":null},{"funder_name":"Joint Research Project of the Science and Technology Department of Guangdong Province","grant_id":"","title":null}],"total_grants":6,"fwci":3.1792,"citation_percentile":0.91858467,"influential_citations":0,"citation_trend":[{"year":2017,"count":3},{"year":2018,"count":7},{"year":2019,"count":7},{"year":2020,"count":11},{"year":2021,"count":11},{"year":2022,"count":8},{"year":2023,"count":9},{"year":2024,"count":4},{"year":2025,"count":3},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006899316307004?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006899316307004?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.brainres.2016.10.008","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27737765","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Medicinal Plants and Neuroprotection","GABA and Rice Research"],"mesh_terms":["Beclin-1","Allylbenzene Derivatives","Acetylcholinesterase","Administration, Oral","Alzheimer Disease","Animals","Anisoles","Autophagy","Disease Models, Animal","Female","Hippocampus","Humans","Learning","Male","Memory","Mice, Inbred C57BL","Mice, Transgenic","Peptide Fragments","Random Allocation","Signal Transduction","Amyloid beta-Peptides","Amyloid beta-Protein Precursor","Nootropic Agents","Presenilin-1"],"keywords":["Genetically modified mouse","Autophagy","Transgene","Cholinesterase","Neuroscience","Cell biology","Amyloid (mycology)","BETA (programming language)","Chemistry","Psychology","Biology","Pharmacology","Biochemistry","Gene","Computer science","Alzheimer’s disease","β-Asarone","Pi3k/akt/mtor Pathway","App/ps1 Transgenic Mice"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T18:11:53.265917Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}