{"doi":"10.1016/j.brainres.2016.07.036","title":"Postnatal development changes in excitatory synaptic activity in the rat locus coeruleus neurons","abstract":null,"journal":"Brain Research","year":2016,"id":678153,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1771871,"name":"Sohrab Hajizadeh","orcid":null,"position":1,"is_corresponding":false},{"id":1771872,"name":"Saeed Semnanian","orcid":null,"position":2,"is_corresponding":false},{"id":1771868,"name":"Masoumeh Kourosh Arami","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Postnatal development changes in excitatory synaptic activity in the rat locus coeruleus neurons","abstract":"Glutamatergic synapses are shown to mature during activity and development. In order to further explore how glutamate can change the excitability of noradrenergic neurons of locus coeruleus (LC) and to better understand the involvement of Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) receptors complements across the LC, we investigated developmental changes in their activity during first postnatal weeks. Spontaneous and evoked excitatory postsynaptic currents (sEPSC and eEPSCs) were recorded in neurons of LC slices from 7, 14 and 21 days old rats using the whole cell patch clamp method. Also, the AMPA/NMDA current ratio (A/N) was measured. A pronounced AMPAR and NMDAR components mediated involvement in synaptic transmission were seen from the first postnatal week. Over this period of development, we have demonstrated that AMPA sEPSCs show an increase in frequency without major changes in their amplitude, while NMDA sEPSCs show an increase in frequency with a major change in amplitude. Neither the probability of release nor the AMPA/NMDA ratio was found to change significantly with age. It is concluded that NMDAR activity as well as AMPAR activity may be involved in coerulear excitability and modulatory effect during postnatal development.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27449899","pmcid":null,"openalex_id":"https://openalex.org/W2498752062","authors":[],"funders":[],"total_grants":0,"fwci":0.1546,"citation_percentile":0.53605057,"influential_citations":0,"citation_trend":[{"year":2019,"count":1},{"year":2020,"count":11},{"year":2022,"count":4},{"year":2023,"count":3},{"year":2025,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006899316305182?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006899316305182?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.brainres.2016.07.036","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27449899","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neural dynamics and brain function","Ion channel regulation and function"],"mesh_terms":["Animals","Locus Coeruleus","Male","Neurons","Receptors, N-Methyl-D-Aspartate","Rats, Wistar","Receptors, AMPA","Excitatory Postsynaptic Potentials","Rats"],"keywords":["AMPA receptor","Excitatory postsynaptic potential","Glutamatergic","Locus coeruleus","NMDA receptor","Neuroscience","Glutamate receptor","Neurotransmission","Chemistry","Postsynaptic potential","Biology","Inhibitory postsynaptic potential","Central nervous system","Receptor","Biochemistry","postnatal development","Ampa Epscs","Nmda Epscs"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T05:00:32.864060Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}