{"doi":"10.1016/j.brainres.2014.11.005","title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","abstract":null,"journal":"Brain Research","year":2015,"id":673119,"datarank":0.7772675325438129,"base_score":5.181783550292085,"endowment":5.181783550292085,"self_citation_contribution":0.7772675325438129,"citation_network_contribution":0.0,"self_endowment_contribution":0.7772675325438129,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":177,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355726,"name":"F. Javier Rubio","orcid":"0000-0001-5480-0474","position":1,"is_corresponding":false},{"id":355729,"name":"Bruce T. Hope","orcid":"0000-0001-5804-7061","position":2,"is_corresponding":false},{"id":1758681,"name":"Fabio C. Cruz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","abstract":"Learned associations between drugs and environment play an important role in addiction and are thought to be encoded within specific patterns of sparsely distributed neurons called neuronal ensembles. This hypothesis is supported by correlational data from in vivo electrophysiology and cellular imaging studies in relapse models in rodents. In particular, cellular imaging with the immediate early gene c-fos and its protein product Fos has been used to identify sparsely distributed neurons that were strongly activated during conditioned drug behaviors such as drug self-administration and context- and cue-induced reinstatement of drug seeking. Here we review how Fos and the c-fos promoter have been employed to demonstrate causal roles for Fos-expressing neuronal ensembles in prefrontal cortex and nucleus accumbens in conditioned drug behaviors. This work has allowed identification of unique molecular and electrophysiological alterations within Fos-expressing neuronal ensembles that may contribute to the development and expression of learned associations in addiction.","is_dataset_classified":null,"base_score":5.181783550292085,"endowment":5.181783550292085,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25446457","pmcid":"PMC4427550","openalex_id":"https://openalex.org/W2007351882","authors":[],"funders":[{"funder_name":"Intramural NIH HHS","grant_id":"ZIA DA000467","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA000467-11","title":null},{"funder_name":"National Institute on Drug Abuse","grant_id":"","title":null}],"total_grants":3,"fwci":4.2992,"citation_percentile":0.95675898,"influential_citations":0,"citation_trend":[{"year":2015,"count":8},{"year":2016,"count":13},{"year":2017,"count":13},{"year":2018,"count":19},{"year":2019,"count":14},{"year":2020,"count":15},{"year":2021,"count":13},{"year":2022,"count":18},{"year":2023,"count":22},{"year":2024,"count":11},{"year":2025,"count":23},{"year":2026,"count":8}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427550","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4427550","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0006899314015522?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006899314015522?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.brainres.2014.11.005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25446457","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Receptor Mechanisms and Signaling","Neurotransmitter Receptor Influence on Behavior","Animals","Behavior, Addictive","Neural Pathways","Neurons","Nucleus Accumbens","Prefrontal Cortex","Proto-Oncogene Proteins c-fos","Substance-Related Disorders"],"mesh_terms":["Animals","Neural Pathways","Neurons","Nucleus Accumbens","Behavior, Addictive","Proto-Oncogene Proteins c-fos","Prefrontal Cortex","Substance-Related Disorders"],"keywords":["Neuroscience","Addiction","Nucleus accumbens","Premovement neuronal activity","Immediate early gene","Context (archaeology)","Psychology","Prefrontal cortex","c-Fos","Electrophysiology","Biology","Gene expression","Central nervous system","Gene","Cognition","Extinction","Self-administration","Conditioned Cues","Drug Environment","Daun02 Inactivation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T12:25:41.570530Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}