{"doi":"10.1016/j.brainres.2004.10.049","title":"Differential distribution of NADPH-diaphorase histochemistry in human cerebral cortex","abstract":null,"journal":"Brain Research","year":2005,"id":606821,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1557976,"name":"Marco Fontanella","orcid":null,"position":1,"is_corresponding":false},{"id":867533,"name":"Simone Tomasi","orcid":"0000-0002-9373-7639","position":2,"is_corresponding":false},{"id":1557977,"name":"Alessandro Ducati","orcid":null,"position":3,"is_corresponding":false},{"id":1436980,"name":"Alessandro Vercelli","orcid":"0000-0002-5909-2128","position":4,"is_corresponding":false},{"id":1557975,"name":"Diego Garbossa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Differential distribution of NADPH-diaphorase histochemistry in human cerebral cortex","abstract":"Beta-nicotinamidedinucleotide phosphate diaphorase (NADPH-d) colocalizes with NOS in the central nervous system. Two types of NADPH-d-positive neurons are present in the primate cerebral cortex: type 1, intensely and Golgi-like labeled neurons, a subset of GABAergic interneurons; type 2, lightly labeled neurons (divided into two subclasses, a first one having a lightly stained cell body bearing only one short process, and a second one showing intense NADPH-d staining with short processes extending radially). We have analyzed the distribution of NADPH-d activity in human frontal, temporal, and occipital cortical areas, finding remarkable laminar and interareal differences in cell size and distribution of the different cell types. There was a clear bias for type 1 neurons in infragranular layers in all areas considered; both in supra- and infragranular layers, their density was highest in frontal, and lowest in temporal cortex. The density of type 2 neurons was lower supragranularly in temporal cortex and infragranularly in occipital cortex. The overall density of type 2 cells was remarkably higher in occipital cortex than in the temporal and frontal ones. Type 1 neurons were significantly larger than type 2, and were smaller in the supragranular than in the infragranular subzone in occipital and temporal cortex. Type 1 cells were significantly larger in frontal cortex than in occipital and temporal cortex, and type 2 cells were significantly smaller in occipital than in temporal and frontal cortex. These area-related differences might reflect differences between heterotypic and homotypic cortex in the regulation of cortical blood flow.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15713254","pmcid":null,"openalex_id":"https://openalex.org/W1993172016","authors":[],"funders":[],"total_grants":0,"fwci":0.5457,"citation_percentile":0.56202061,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2020,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0006899304017779?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0006899304017779?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.brainres.2004.10.049","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15713254","host_type":"repository"},{"url":"http://hdl.handle.net/11379/157907","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Neuroinflammation and Neurodegeneration Mechanisms","Retinal Development and Disorders","Axons","Brain Mapping","Cell Count","Cell Shape","Cerebral Cortex","Cerebrovascular Circulation","Dendrites","Female","Frontal Lobe","Histocytochemistry","Humans","Male","Middle Aged","NADPH Dehydrogenase","Neurons","Nitric Oxide","Nitric Oxide Synthase","Occipital Lobe","Temporal Lobe","gamma-Aminobutyric Acid"],"mesh_terms":["Axons","Brain Mapping","Cell Count","Cerebral Cortex","Cerebrovascular Circulation","Dendrites","Female","Frontal Lobe","gamma-Aminobutyric Acid","Histocytochemistry","Humans","Male","Middle Aged","NADPH Dehydrogenase","Neurons","Nitric Oxide","Occipital Lobe","Temporal Lobe","Nitric Oxide Synthase","Cell Shape"],"keywords":["Cortex (anatomy)","Cerebral cortex","Neuroscience","Temporal cortex","GABAergic","Anatomy","Chemistry","Biology","Inhibitory postsynaptic potential"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T05:13:49.639983Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}