{"doi":"10.1016/j.brain.2024.100100","title":"Increased hindbrain motion in Chiari I malformation patients measured through 3D amplified MRI (3D aMRI)","abstract":"Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects including excessive cerebellar tonsillar ectopia and associated manifestations. We used 3D amplified MRI on a cohort of healthy and CM-I subjects to investigate the brain’s intrinsic motion, its association with the morphology and patient’s symptomatology , and surgical outcomes. We observed that the regional brain motion in CM-I was significantly higher than that of the healthy subjects, with anterior-posterior (AP) and superior-inferior (SI) displacements in cerebellar tonsils and medulla having the highest differences between the healthy and CM-I ( ∼ 45%– ∼ 73% increased motion in the CM-I group). Interestingly, we found the ratio of neural tissue in the foramen magnum to be directly correlated with the SI tonsillar motion ( r = 0 . 58 ). Tonsillar herniation was directly correlated with the AP motion of the tonsils ( r = 0 . 61 ), and AP and medial-lateral (ML) motions of the medulla ( r = 0 . 66 , and r = 0 . 57 ). Subjects with higher tonsillar ML motion prior to surgery showed improved outcome ( p = 0 . 03 , and A U C = 0 . 95 ). Although we did not observe a significant correlation between the brains motion and morphometrics on the CM-I symptoms (perhaps due to our small sample size), illustrative cases increase our hope for the development of a future tool based on brain biomechanics.","journal":"Brain Multiphysics","year":2024,"id":458468,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1285254,"name":"Fargol Rezayaraghi","orcid":null,"position":1,"is_corresponding":false},{"id":392628,"name":"Aymeric Pionteck","orcid":"0000-0003-1228-6782","position":2,"is_corresponding":false},{"id":988297,"name":"Ya‐Chen Chuang","orcid":"0000-0002-6864-6356","position":3,"is_corresponding":false},{"id":988298,"name":"Alejandro Carrasquilla","orcid":"0000-0001-7304-1784","position":4,"is_corresponding":false},{"id":988819,"name":"Gizem Bilgili","orcid":null,"position":5,"is_corresponding":false},{"id":1284758,"name":"Tianyi Ren","orcid":"0000-0001-9548-6645","position":6,"is_corresponding":false},{"id":1285255,"name":"Tyson Lam","orcid":null,"position":7,"is_corresponding":false},{"id":1178229,"name":"Tse-An Lu","orcid":null,"position":8,"is_corresponding":false},{"id":583096,"name":"Miriam Scadeng","orcid":"0000-0002-9593-2956","position":9,"is_corresponding":false},{"id":971150,"name":"Patrick Fillingham","orcid":"0000-0002-8139-7331","position":10,"is_corresponding":false},{"id":302623,"name":"Peter Morgenstern","orcid":"0000-0002-2409-3614","position":11,"is_corresponding":false},{"id":232550,"name":"Michael R. Levitt","orcid":"0000-0003-3612-3347","position":12,"is_corresponding":false},{"id":23044,"name":"Richard G. Ellenbogen","orcid":"0000-0002-3463-1009","position":13,"is_corresponding":false},{"id":106869,"name":"Yang Yang","orcid":"0000-0002-2841-4243","position":14,"is_corresponding":false},{"id":392629,"name":"Samantha J. Holdsworth","orcid":"0000-0002-2929-1169","position":15,"is_corresponding":false},{"id":469389,"name":"Raj Shrivastava","orcid":"0000-0002-7454-8525","position":16,"is_corresponding":false},{"id":392630,"name":"Mehmet Kurt","orcid":"0000-0002-5618-0296","position":17,"is_corresponding":false},{"id":392624,"name":"Javid Abderezaei","orcid":"0000-0001-5236-7582","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:03:50.608887Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}