{"doi":"10.1016/j.bpsgos.2025.100604","title":"Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients","abstract":"Background: Functional seizures (FS) are paroxysmal episodes that phenotypically resemble epileptic seizures but are not associated with brain epileptiform discharges; they are also known as psychogenic nonepileptic seizures. The exact etiology and pathophysiology of FS is unknown; however, trauma and stress-related disorders are known risk factors. Methods: We used a validated algorithm applied to electronic health records to identify individuals with FS in 6 international biobanks and hospital sites. We conducted a multisite FS genome-wide association study (GWAS) meta-analysis, including 10,910 FS cases (9040 predicted European ancestry [EA] and 1870 predicted African ancestry [AA]) and 664,500 (561,150 EA and 103,350 AA) control participants. Results: ). Conclusions: To our knowledge, this is the first GWAS of FS, and our results support a genetic basis of FS. Future large-scale genetic research studies are needed to corroborate these findings and identify genetic variants associated with FS.","journal":"Biological Psychiatry Global Open Science","year":2025,"id":573972,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10206,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6863,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297280,"name":"Costin Leu","orcid":"0000-0003-0598-3301","position":1,"is_corresponding":false},{"id":230961,"name":"Yen‐Chen Anne Feng","orcid":"0000-0003-2116-3645","position":2,"is_corresponding":false},{"id":867531,"name":"David Burstein","orcid":"0000-0003-0615-8178","position":3,"is_corresponding":false},{"id":696670,"name":"Sanan Venkatesh","orcid":"0000-0002-3094-2731","position":4,"is_corresponding":false},{"id":460846,"name":"Rebecca Birnbaum","orcid":"0000-0002-4206-4323","position":5,"is_corresponding":false},{"id":556293,"name":"Veera M. Rajagopal","orcid":"0000-0002-5236-168X","position":6,"is_corresponding":false},{"id":11369,"name":"Péter Straub","orcid":"0009-0009-9693-8207","position":7,"is_corresponding":false},{"id":367696,"name":"Jakob Christensen","orcid":"0000-0002-9385-6435","position":8,"is_corresponding":false},{"id":1214232,"name":"Jocelyn F. Bautista","orcid":null,"position":9,"is_corresponding":false},{"id":295664,"name":"Robyn M. Busch","orcid":"0000-0002-5442-4912","position":10,"is_corresponding":false},{"id":655343,"name":"Imad Najm","orcid":"0000-0001-5192-2089","position":11,"is_corresponding":false},{"id":104396,"name":"Jakob Grove","orcid":"0000-0003-2284-5744","position":12,"is_corresponding":false},{"id":5363,"name":"Anders D. Børglum","orcid":"0000-0001-8627-7219","position":13,"is_corresponding":false},{"id":1200,"name":"Georgios Voloudakis","orcid":"0000-0002-5729-632X","position":14,"is_corresponding":false},{"id":1203,"name":"Panos Roussos","orcid":"0000-0002-4640-6239","position":15,"is_corresponding":false},{"id":104618,"name":"Jordan W. Smoller","orcid":"0000-0002-0381-6334","position":16,"is_corresponding":false},{"id":297266,"name":"Dennis Lal","orcid":"0000-0002-5173-9636","position":17,"is_corresponding":false},{"id":11243,"name":"Lea K. Davis","orcid":"0000-0001-5143-2282","position":18,"is_corresponding":false},{"id":477291,"name":"Slavina B. Goleva","orcid":"0000-0001-5177-9286","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:57:36.753600Z","pmid":"41234274","pmcid":"PMC12607027","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}