{"doi":"10.1016/j.bpsgos.2024.100332","title":"Identification of State Markers in Anorexia Nervosa: Replication and Extension of Inflammation-Associated Biomarkers Using Multiplex Profiling","abstract":"Background: Proteomics offers potential for detecting and monitoring anorexia nervosa (AN) and its variant, atypical AN (atyp-AN). However, research has been limited by small protein panels, a focus on adult AN, and lack of replication. Methods: = 44). Results: Five proteins differed significantly between the primary AN/atyp-AN group and the healthy control group (lower levels: HGF, IL-18R1, TRANCE; higher levels: CCL23, LIF-R). The expression levels of 3 proteins (lower IL-18R1, TRANCE; higher LIF-R) were uniquely disrupted in participants with AN in our primary model. No unique expression levels emerged for atyp-AN. In the total sample, 12 proteins (ADA, CD5, CD6, CXCL1, FGF-21, HGF, IL-12B, IL18, IL-18R1, SIRT2, TNFSF14, TRANCE) were positively correlated with body mass index and 5 proteins (CCL11, FGF-19, IL8, LIF-R, OPG) were negatively correlated with body mass index in our primary models. Conclusions: Our results replicate the results of a previous study that demonstrated a dysregulated inflammatory status in AN and extend those results to atyp-AN. Of the 17 proteins correlated with body mass index, 11 were replicated from a previous study that used similar methods, highlighting the promise of inflammatory protein expression levels as biomarkers of AN disease monitoring. Our findings underscore the complexity of AN and atyp-AN by highlighting the inability of the identified proteins to differentiate between these 2 subtypes, thereby emphasizing the heterogeneous nature of these disorders.","journal":"Biological Psychiatry Global Open Science","year":2024,"id":436663,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368938,"name":"Laura M. Holsen","orcid":"0000-0003-1292-7789","position":1,"is_corresponding":false},{"id":911665,"name":"Chunni Ji","orcid":"0000-0002-6733-9696","position":2,"is_corresponding":false},{"id":230959,"name":"Jie Hu","orcid":"0000-0001-8282-4895","position":3,"is_corresponding":false},{"id":855141,"name":"Felicia Petterway","orcid":"0000-0001-9742-0957","position":4,"is_corresponding":false},{"id":440106,"name":"Megan E. Rosa‐Caldwell","orcid":"0000-0002-3829-1021","position":5,"is_corresponding":false},{"id":1245028,"name":"Ida Nilsson","orcid":"0000-0002-7676-4299","position":6,"is_corresponding":false},{"id":767777,"name":"Jennifer J. Thomas","orcid":"0000-0003-2601-581X","position":7,"is_corresponding":false},{"id":310634,"name":"Kyle A. Williams","orcid":"0000-0003-3969-3548","position":8,"is_corresponding":false},{"id":1191879,"name":"Regine Boutin","orcid":"0009-0003-3976-5676","position":9,"is_corresponding":false},{"id":706224,"name":"Meghan Slattery","orcid":"0000-0001-7123-0661","position":10,"is_corresponding":false},{"id":112587,"name":"Cynthia M. Bulik","orcid":"0000-0001-7772-3264","position":11,"is_corresponding":false},{"id":282975,"name":"Steven E. Arnold","orcid":"0000-0002-9487-415X","position":12,"is_corresponding":false},{"id":640393,"name":"Elizabeth A. Lawson","orcid":"0000-0001-8619-3349","position":13,"is_corresponding":false},{"id":388582,"name":"Madhusmita Misra","orcid":"0000-0002-9405-2981","position":14,"is_corresponding":false},{"id":706227,"name":"Kamryn T. Eddy","orcid":"0000-0002-1586-0930","position":15,"is_corresponding":false},{"id":786917,"name":"Lauren Breithaupt","orcid":"0000-0002-2439-6519","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:16.989773Z","pmid":"38989135","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}