{"doi":"10.1016/j.bpsgos.2023.08.018","title":"Age-Related Alterations in Gray Matter Microstructure in Older People With Remitted Major Depression at Risk for Dementia","abstract":"Background: Major depressive disorder (MDD) in late life is a risk factor for mild cognitive impairment (MCI) and Alzheimer's disease. However, studies of gray matter changes have produced varied estimates of which structures are implicated in MDD and dementia. Changes in gray matter volume and cortical thickness are macrostructural measures for the microstructural processes of free water accumulation and dendritic spine loss. Methods: = 24). We estimated measures related to neurite density, orientation dispersion, and free water (isotropic volume fraction) using a biophysically plausible model (neurite orientation dispersion and density imaging). Results: Results showed that increasing age was correlated with an increase in isotropic volume fraction and a decrease in orientation dispersion index, which is consistent with neuropathology dendritic loss. In addition, this relationship between age and increased isotropic volume fraction was more disrupted in the MCI group than in the remitted MDD or healthy control groups. However, the association between age and orientation dispersion index was similar for all 3 groups. Conclusions: The findings suggest that the neurite orientation dispersion and density imaging measures could be used to identify biological risk factors for Alzheimer's disease, signifying both conventional neurodegeneration observed with MCI and dendritic loss seen in MDD.","journal":"Biological Psychiatry Global Open Science","year":2023,"id":367392,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9639,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":502850,"name":"Neda Rashidi‐Ranjbar","orcid":"0000-0002-2125-1090","position":1,"is_corresponding":false},{"id":294407,"name":"Arash Nazeri","orcid":"0000-0001-6983-0641","position":2,"is_corresponding":false},{"id":726623,"name":"Jordan A. Chad","orcid":null,"position":3,"is_corresponding":false},{"id":777359,"name":"Peter Zhukovsky","orcid":"0000-0002-7181-2095","position":4,"is_corresponding":false},{"id":226870,"name":"Benoit H. Mulsant","orcid":"0000-0002-0303-6450","position":5,"is_corresponding":false},{"id":244608,"name":"Nathan Herrmann","orcid":"0000-0001-9277-6110","position":6,"is_corresponding":false},{"id":490603,"name":"Linda Mah","orcid":"0000-0001-5268-8861","position":7,"is_corresponding":false},{"id":3107,"name":"Alastair J. Flint","orcid":"0000-0001-6806-0235","position":8,"is_corresponding":false},{"id":291331,"name":"Corinne E. Fischer","orcid":"0000-0002-1047-0167","position":9,"is_corresponding":false},{"id":226869,"name":"Bruce G. Pollock","orcid":"0000-0003-0802-3998","position":10,"is_corresponding":false},{"id":226868,"name":"Tarek K. Rajji","orcid":"0000-0002-8324-2560","position":11,"is_corresponding":false},{"id":230416,"name":"Aristotle N. Voineskos","orcid":"0000-0003-0156-0395","position":12,"is_corresponding":false},{"id":502851,"name":"John A. E. Anderson","orcid":"0000-0001-6511-1957","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:15:12.215513Z","pmid":"38298786","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}