{"doi":"10.1016/j.bpsgos.2023.08.012","title":"Rumination-Focused Cognitive Behavioral Therapy Reduces Rumination and Targeted Cross-network Connectivity in Youth With a History of Depression: Replication in a Preregistered Randomized Clinical Trial","abstract":"Rumination-focused cognitive behavioral therapy (RF-CBT) is designed to reduce depressive rumination or the habitual tendency to dwell on experiences in a repetitive, negative, passive, and global manner. RF-CBT uses functional analysis, experiential exercises, and repeated practice to identify and change the ruminative habit. This preregistered randomized clinical trial (NCT03859297, R61) is a preregistered replication of initial work. We hypothesized a concurrent reduction of both self-reported rumination and cross-network connectivity between the left posterior cingulate cortex and right inferior frontal and inferior temporal gyri. Seventy-six youths with a history of depression and elevated rumination were randomized to 10 to 14 sessions of RF-CBT (n = 39; 34 completers) or treatment as usual (n = 37; 28 completers). Intent-to-treat analyses assessed pre-post change in rumination response scale and in functional connectivity assessed using two 5 minute, 12 second runs of resting-state functional magnetic resonance imaging. We replicated previous findings: a significant reduction in rumination response scale and a reduction in left posterior cingulate cortex to right inferior frontal gyrus/inferior temporal gyrus connectivity in participants who received RF-CBT compared with those who received treatment as usual. Reductions were large (z change = 0.84; 0.73, respectively [ps < .05]). This adolescent clinical trial further demonstrates that depressive rumination is a brain-based mechanism that is modifiable via RF-CBT. Here, we replicated that RF-CBT reduces cross-network connectivity, a possible mechanism by which rumination becomes less frequent, intense, and automatic. This National Institute of Mental Health-funded fast-fail study continues to the R33 phase during which treatment-specific effects of RF-CBT will be compared with relaxation therapy.","journal":"Biological Psychiatry Global Open Science","year":2023,"id":327455,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477455,"name":"Mindy Westlund Schreiner","orcid":"0000-0002-2780-3327","position":1,"is_corresponding":false},{"id":975652,"name":"Katie L. Bessette","orcid":"0000-0002-7423-4884","position":2,"is_corresponding":false},{"id":1047641,"name":"Henrietta Roberts","orcid":"0000-0002-0831-2645","position":3,"is_corresponding":false},{"id":1047642,"name":"Leah Thomas","orcid":"0009-0005-0735-4383","position":4,"is_corresponding":false},{"id":975648,"name":"Alina Dillahunt","orcid":"0000-0002-6389-9725","position":5,"is_corresponding":false},{"id":976124,"name":"Stephanie Pocius","orcid":null,"position":6,"is_corresponding":false},{"id":1029550,"name":"Daniel Feldman","orcid":"0000-0003-1644-7504","position":7,"is_corresponding":false},{"id":1048130,"name":"Dave Jago","orcid":null,"position":8,"is_corresponding":false},{"id":1047643,"name":"Brian Farstead","orcid":"0000-0002-9919-0769","position":9,"is_corresponding":false},{"id":1047644,"name":"Myah Pazdera","orcid":"0000-0003-1610-4157","position":10,"is_corresponding":false},{"id":858786,"name":"Erin A. Kaufman","orcid":"0000-0002-7636-6602","position":11,"is_corresponding":false},{"id":1048131,"name":"Jennica Galloway","orcid":null,"position":12,"is_corresponding":false},{"id":740133,"name":"Patricia K. Kerig","orcid":"0000-0001-8836-1967","position":13,"is_corresponding":false},{"id":267629,"name":"Amanda V. Bakian","orcid":"0000-0001-6805-1160","position":14,"is_corresponding":false},{"id":1047645,"name":"Robert C. Welsh","orcid":"0000-0002-8701-694X","position":15,"is_corresponding":false},{"id":1047646,"name":"Rachel H. Jacobs","orcid":"0000-0003-4951-2704","position":16,"is_corresponding":false},{"id":267630,"name":"Sheila E. Crowell","orcid":"0000-0003-1296-6614","position":17,"is_corresponding":false},{"id":1020846,"name":"Edward Watkins","orcid":"0000-0002-2432-5577","position":18,"is_corresponding":false},{"id":392549,"name":"Scott A. Langenecker","orcid":"0000-0002-7932-5494","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:08:42.846627Z","pmid":"38021251","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}