{"doi":"10.1016/j.bpsgos.2023.03.003","title":"Genetic Decomposition of the Heritable Component of Reported Childhood Maltreatment","abstract":"Decades of research have shown that environmental exposures, including self-reports of trauma, are partly heritable. Heritable characteristics may influence exposure to and interpretations of environmental factors. Identifying heritable factors associated with self-reported trauma could improve our understanding of vulnerability to exposure and the interpretation of life events. We used genome-wide association study summary statistics of childhood maltreatment, defined as reporting of abuse (emotional, sexual, and physical) and neglect (emotional and physical) (N = 185,414 participants). We calculated genetic correlations (rg) between reported childhood maltreatment and 576 traits to identify phenotypes that might explain the heritability of reported childhood maltreatment, retaining those with |rg| > 0.25. We specified multiple regression models using genomic structural equation modeling to detect residual genetic variance in childhood maltreatment after accounting for genetically correlated traits. In 2 separate models, the shared genetic component of 12 health and behavioral traits and 7 psychiatric disorders accounted for 59% and 56% of heritability due to common genetic variants (single nucleotide polymorphism–based heritability [h2SNP]) of childhood maltreatment, respectively. Genetic influences on h2SNP of childhood maltreatment were generally accounted for by a shared genetic component across traits. The exceptions to this were general risk tolerance, subjective well-being, posttraumatic stress disorder, and autism spectrum disorder, identified as independent contributors to h2SNP of childhood maltreatment. These 4 traits alone were sufficient to explain 58% of h2SNP of childhood maltreatment. We identified putative traits that reflect h2SNP of childhood maltreatment. Elucidating the mechanisms underlying these associations may improve trauma prevention and posttraumatic intervention strategies.","journal":"Biological Psychiatry Global Open Science","year":2023,"id":357722,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9446,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304138,"name":"Christopher Hübel","orcid":"0000-0002-1267-8287","position":1,"is_corresponding":false},{"id":486143,"name":"Rosa Cheesman","orcid":"0000-0002-6543-0402","position":2,"is_corresponding":false},{"id":176,"name":"Jonathan R. I. Coleman","orcid":"0000-0002-6759-0944","position":3,"is_corresponding":false},{"id":653847,"name":"Alicia J. Peel","orcid":"0000-0002-6144-5412","position":4,"is_corresponding":false},{"id":869427,"name":"Daniel Levey","orcid":null,"position":5,"is_corresponding":false},{"id":22832,"name":"Murray B Stein","orcid":"0000-0001-9564-2871","position":6,"is_corresponding":false},{"id":230005,"name":"Joel Gelernter","orcid":"0000-0002-4067-1859","position":7,"is_corresponding":false},{"id":1048468,"name":"Christopher Rayner","orcid":"0000-0003-2950-343X","position":8,"is_corresponding":false},{"id":5216,"name":"Thalia C. Eley","orcid":"0000-0001-6458-0700","position":9,"is_corresponding":false},{"id":215,"name":"Gerome Breen","orcid":"0000-0003-2053-1792","position":10,"is_corresponding":false},{"id":653851,"name":"Abigail ter Kuile","orcid":"0000-0002-7869-3754","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:13:39.186262Z","pmid":"37881567","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}