{"doi":"10.1016/j.bpsgos.2022.07.006","title":"Associations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators","abstract":"The ongoing COVID-19 pandemic is a major stressor that has been associated with increased risk for psychiatric illness in the general population. Recent work has highlighted that experiences of early-life stress (ELS) may impact individuals’ psychological functioning and vulnerability for developing internalizing psychopathology in response to pandemic-related stress. However, little is known about the neurobehavioral factors that may mediate the association between ELS exposure and COVID-related internalizing symptomatology. The current study sought to examine the mediating roles of pre-pandemic resting-state frontoamygdala connectivity and concurrent emotion regulation (ER) in the association between ELS and pandemic-related internalizing symptomatology. Retrospective life-stress histories, concurrent self-reported ER strategies (i.e., reappraisal and suppression), concurrent self-reported internalizing symptomatology (i.e., depression- and anxiety-related symptomatology), and resting-state functional connectivity data from a sample of adults (N = 64, Mage = 22.12, female = 68.75%) were utilized. There were no significant direct associations between ELS and COVID-related internalizing symptomatology. Neither frontoamygdala functional connectivity nor ER strategy use mediated an association between ELS and COVID-related internalizing symptomatology (ps > 0.05). Exploratory analyses identified a significant moderating effect of reappraisal use on the association between ELS and internalizing symptomatology (β = -0.818, p = 0.047), such that increased reappraisal use buffered the impact of ELS on psychopathology. While frontoamygdala connectivity and ER do not appear to mediate the association between ELS and COVID-related internalizing symptomatology, our findings suggest that the use of reappraisal may buffer against the effect of ELS on mental health during the pandemic.","journal":"Biological Psychiatry Global Open Science","year":2022,"id":292621,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263180,"name":"Emily M. Cohodes","orcid":"0000-0002-0167-3392","position":1,"is_corresponding":false},{"id":649385,"name":"Alexis Brieant","orcid":"0000-0003-3430-4427","position":2,"is_corresponding":false},{"id":632031,"name":"Sarah McCauley","orcid":"0000-0003-4619-0156","position":3,"is_corresponding":false},{"id":322783,"name":"Paola Odriozola","orcid":"0000-0003-1641-4139","position":4,"is_corresponding":false},{"id":650085,"name":"Sadie J. Zacharek","orcid":"0000-0001-8770-4614","position":5,"is_corresponding":false},{"id":976705,"name":"Jasmyne C. Pierre","orcid":"0000-0003-2010-6278","position":6,"is_corresponding":false},{"id":650084,"name":"Hopewell R. Hodges","orcid":"0000-0001-9228-6365","position":7,"is_corresponding":false},{"id":650083,"name":"Sahana Kribakaran","orcid":"0000-0002-4254-8715","position":8,"is_corresponding":false},{"id":964692,"name":"Jason T. Haberman","orcid":null,"position":9,"is_corresponding":false},{"id":326852,"name":"Bailey Holt-Gosselin","orcid":"0000-0003-4424-2901","position":10,"is_corresponding":false},{"id":263182,"name":"Dylan G. Gee","orcid":"0000-0002-3685-2710","position":11,"is_corresponding":false},{"id":964691,"name":"Jordan C. Foster","orcid":null,"position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":null,"created_at":"2026-07-19T00:30:46.209549Z","pmid":"35959474","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}