{"doi":"10.1016/j.bpsc.2025.10.002","title":"Connectome-Based Predictive Models Optimized for Sleep Differentiate Patients With Depression From Psychiatrically Healthy Controls","abstract":"BACKGROUND: It is unknown whether brain-based predictive models derived from sleep features are useful for the clinical diagnosis of major depressive disorder (MDD). METHODS: Using resting-state functional magnetic resonance imaging data from the curated ABCD (Adolescent Brain Cognitive Development) Study Data Release 3.0, we trained a connectome-based predictive model (CPM) on 35,778 pairwise connections (Pearson's r) from 2349 (237 participants with at least 1 psychiatric disorder and 2112 control participants) participants ages 11 to 12 to predict sleep duration (measured from a Fitbit tracker). Linear regression models were used to compare the predicted values from these CPMs with self-reported sleep duration and diagnostic group status in an independent cohort of 78 participants (57 participants with MDD and 21 control participants) ages 14 to 18. RESULTS: = 0.13, p = .90), the ABCD-based CPM successfully distinguished between diagnostic groups (partial r = 0.334, p < .001), and CPM-predicted sleep durations correlated with depression symptom severity (partial r = 0.294, p < .001). These diagnostic group differences were driven primarily by patterns of hypoconnectivity within various resting-state networks (including the default mode, frontoparietal, motor, and subcortical networks). CONCLUSIONS: CPMs trained to predict objective sleep duration are robust and generalizable. Intrinsic functional connectivity differences between clinically depressed and psychiatrically healthy adolescents are detectable by CPMs optimized for sleep prediction, underscoring the shared neural bases between sleep health and depression. Future work will test whether sleep-based CPMs are predictive of clinical course and if they generalize to other disorders beyond depression.","journal":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","year":2025,"id":578388,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.93,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":755827,"name":"Carolyn Amir","orcid":"0000-0001-9078-8564","position":1,"is_corresponding":false},{"id":1488000,"name":"Nicholas B. Allen","orcid":"0000-0002-4866-125X","position":2,"is_corresponding":false},{"id":109314,"name":"Tiffany C. Ho","orcid":"0000-0002-4500-6364","position":3,"is_corresponding":false},{"id":1161204,"name":"Anurima Mummaneni","orcid":"0000-0003-0661-0101","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:58:20.638044Z","pmid":"41109569","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}