{"doi":"10.1016/j.bpsc.2016.10.003","title":"Reward-Related Ventral Striatum Activity Links Polygenic Risk for Attention-Deficit/Hyperactivity Disorder to Problematic Alcohol Use in Young Adulthood","abstract":null,"journal":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging","year":2017,"id":632639,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107831,"name":"Annchen R. Knodt","orcid":"0000-0001-6501-8947","position":1,"is_corresponding":false},{"id":80312,"name":"Emily Drabant Conley","orcid":null,"position":2,"is_corresponding":false},{"id":109920,"name":"Ahmad R. Hariri","orcid":"0000-0003-3052-9880","position":3,"is_corresponding":false},{"id":232788,"name":"Ryan Bogdan","orcid":"0000-0002-1430-1045","position":4,"is_corresponding":false},{"id":556044,"name":"Caitlin E. Carey","orcid":"0000-0002-4953-5351","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Reward-Related Ventral Striatum Activity Links Polygenic Risk for Attention-Deficit/Hyperactivity Disorder to Problematic Alcohol Use in Young Adulthood","abstract":"<h4>Background</h4>Problematic alcohol use in adolescence and adulthood is a common and often debilitating correlate of childhood attention-deficit/hyperactivity disorder (ADHD). Converging evidence suggests that ADHD and problematic alcohol use share a common additive genetic basis, which may be mechanistically related to reward-related brain function. In the current study, we examined whether polygenic risk for childhood ADHD is linked to problematic alcohol use in young adulthood through alterations in reward-related activity of the ventral striatum, a neural hub supporting appetitive behaviors and reinforcement learning.<h4>Methods</h4>Genomic, neuroimaging, and self-report data were available for 404 non-Hispanic European-American participants who completed the ongoing Duke Neurogenetics Study. Polygenic risk scores for childhood ADHD were calculated based on a genome-wide association study meta-analysis conducted by the Psychiatric Genomics Consortium and tested for association with reward-related ventral striatum activity, measured using a number-guessing functional magnetic resonance imaging paradigm, and self-reported problematic alcohol use. A mediational model tested whether ventral striatum activity indirectly links polygenic risk for ADHD to problematic alcohol use.<h4>Results</h4>Despite having no main effect on problematic alcohol use, polygenic risk for childhood ADHD was indirectly associated with problematic alcohol use through increased reward-related ventral striatum activity.<h4>Conclusions</h4>Individual differences in reward-related brain function may, at least in part, mechanistically link polygenic risk for childhood ADHD to problematic alcohol use.","is_dataset_classified":null,"base_score":3.091042453358316,"endowment":3.091042453358316,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28825048","pmcid":"PMC5560771","openalex_id":"https://openalex.org/W2540285927","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG045231","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD083614","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG049789","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA033369","title":null}],"total_grants":4,"fwci":2.4482,"citation_percentile":0.88675763,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":5},{"year":2019,"count":4},{"year":2020,"count":1},{"year":2021,"count":5},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5560771","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5560771","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S2451902216301471?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2451902216301471?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bpsc.2016.10.003","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28825048","host_type":"repository"}],"fields_of_study":["Attention Deficit Hyperactivity Disorder","Neurotransmitter Receptor Influence on Behavior","Substance Abuse Treatment and Outcomes"],"mesh_terms":[],"keywords":["Ventral striatum","Striatum","Psychology","Attention deficit hyperactivity disorder","Alcohol use disorder","Attention deficit disorder","Alcohol","Polygenic risk score","Attention deficit","Gambling disorder","Neuroscience","Psychiatry","Developmental psychology","Addiction","Clinical psychology","Dopamine","Biology","Genetics","Gene","fMRI","ADHD","Reward","Polygenic"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:06:04.881448Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}