{"doi":"10.1016/j.bpobgyn.2021.10.010","title":"Menopause review: Emerging treatments for menopausal symptoms","abstract":null,"journal":"Best Practice & Research Clinical Obstetrics & Gynaecology","year":2022,"id":630196,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":238270,"name":"Waljit S. Dhillo","orcid":"0000-0001-5950-4316","position":1,"is_corresponding":false},{"id":82080,"name":"Bijal Patel","orcid":"0000-0002-1709-2410","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Menopause review: Emerging treatments for menopausal symptoms","abstract":"Vasomotor symptoms (VMS) affect 2 out of 3 women during menopause and are highly disruptive and intolerable. They exert a negative impact on a woman's physical and mental well-being and are considered a high clinical priority requiring effective treatment. Although hormone therapy remains the gold-standard treatment for hot flushes, it is associated with several side effects and contraindications. Furthermore, alternative treatments for VMS are currently less efficacious and have limited availability; therefore, a new medication to treat VMS would benefit millions of women worldwide. Neurokinin 3 receptor (NK3R) antagonists have recently been developed as novel therapeutic agents for the amelioration of VMS through their action on NK3 receptors within the hypothalamus and consequent regulation of the thermoregulatory centre. So far, three NK3R antagonists have been studied in menopausal women, which have demonstrated significant reductions in VMS frequency and severity and have shown their ability to transform patients' quality of life.","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34965909","pmcid":null,"openalex_id":"https://openalex.org/W3214644443","authors":[],"funders":[{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"NIHR202371","title":null},{"funder_name":"National Institute for Health Research (NIHR)","grant_id":"RP-2014-05-001","title":null},{"funder_name":"Manchester Biomedical Research Centre","grant_id":"","title":null},{"funder_name":"Imperial Health Charity","grant_id":"","title":null},{"funder_name":"National Institute for Health and Care Research","grant_id":"","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"","title":null},{"funder_name":"Medical Research Council","grant_id":"","title":null},{"funder_name":"NIHR Imperial Biomedical Research Centre","grant_id":"","title":null}],"total_grants":8,"fwci":6.5995,"citation_percentile":0.97808629,"influential_citations":0,"citation_trend":[{"year":2022,"count":36},{"year":2023,"count":6},{"year":2024,"count":7},{"year":2025,"count":12},{"year":2026,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.1016/j.bpobgyn.2021.10.010","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34965909","host_type":"repository"}],"fields_of_study":["Menopause: Health Impacts and Treatments","Hypothalamic control of reproductive hormones","Estrogen and related hormone effects","Female","Hot Flashes","Humans","Menopause","Quality of Life","Treatment Outcome"],"mesh_terms":["Female","Humans","Menopause","Quality of Life","Treatment Outcome","Hot Flashes"],"keywords":["Medicine","Vasomotor","Menopause","Quality of life (healthcare)","Internal medicine","Vasomotor Symptoms","Neurokinin 3-Receptor Antagonist"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T20:39:13.988319Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}