{"doi":"10.1016/j.bpc.2011.06.009","title":"A biophysical model of intracellular distribution and perinuclear accumulation of particulate matter","abstract":null,"journal":"Biophysical Chemistry","year":2011,"id":670215,"datarank":0.38474240361923057,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.0,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":496346,"name":"Alice Panariti","orcid":"0000-0002-0809-326X","position":1,"is_corresponding":false},{"id":703768,"name":"Maddalena Collini","orcid":"0000-0002-6240-0216","position":2,"is_corresponding":false},{"id":1750547,"name":"Barbara Lettiero","orcid":null,"position":3,"is_corresponding":false},{"id":1750548,"name":"Laura D'Alfonso","orcid":null,"position":4,"is_corresponding":false},{"id":703767,"name":"Laura Sironi","orcid":"0000-0002-6638-7709","position":5,"is_corresponding":false},{"id":655037,"name":"Giuseppe Miserocchi","orcid":"0000-0002-4474-8059","position":6,"is_corresponding":false},{"id":1750549,"name":"Giuseppe Chirico","orcid":null,"position":7,"is_corresponding":false},{"id":395431,"name":"Ilaria Rivolta","orcid":"0000-0002-7411-9069","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A biophysical model of intracellular distribution and perinuclear accumulation of particulate matter","abstract":"We have measured in human alveolar cells the cytoplasmic distribution of the fluorophore coumarin-6 carried by Solid Lipid Nanoparticles (SLNs) and observed a perinuclear accumulation of the fluorescence that can be described by a single exponential growth along an ideal line joining the plasma membrane to the nuclear border and by a sigmoidal relationship as a function of time. Intracellular distribution was affected by lowering the temperature from 37 to 4° C and by the disruption of cytoskeleton by cytochalasin D, but it was minimally perturbed by the inhibition of ATP dependent molecular motors. A biophysical model was developed for an accumulation of loaded particles against a diffusion gradient based on a mean field interaction energy, whose origin we ascribe to the actin structure of the cytoskeleton. The estimated value for the load diffusion coefficient was four and two orders of magnitude less than that of free coumarin-6 and of SLNs in aqueous solutions, respectively, suggesting that the load moves within the cell cytoplasm in a form still reminiscent of the nanocarrier structure.","is_dataset_classified":null,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21741753","pmcid":null,"openalex_id":"https://openalex.org/W1963597769","authors":[],"funders":[{"funder_name":"European Commission","grant_id":"201842","title":"European Network for Cell Imaging and Tracking Expertise"}],"total_grants":1,"fwci":0.7302,"citation_percentile":0.67424434,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":2},{"year":2014,"count":1},{"year":2016,"count":1},{"year":2020,"count":1},{"year":2023,"count":1},{"year":2024,"count":3}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://hal.science/hal-00778541","host_type":"repository"},{"url":"https://hal.science/hal-00778541","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0301462211002067?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0301462211002067?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bpc.2011.06.009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21741753","host_type":"repository"},{"url":"http://hdl.handle.net/10281/48225","host_type":"repository"},{"url":"http://hdl.handle.net/2262/65921","host_type":"repository"},{"url":"https://hal.archives-ouvertes.fr/hal-00778541/document","host_type":""},{"url":"https://hal.science/hal-00778541v1","host_type":""},{"url":"https://hal.science/hal-00778541v1/document","host_type":""},{"url":"https://dx.doi.org/10.1016/j.bpc.2011.06.009","host_type":""},{"url":"https://hdl.handle.net/10281/48225","host_type":""}],"fields_of_study":["Lipid Membrane Structure and Behavior","Electrostatics and Colloid Interactions","Nanoparticle-Based Drug Delivery","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Line","Cell Membrane Permeability","Coumarins","Cytoplasm","Cytoskeleton","Diffusion","Humans","Models, Biological","Nanoparticles","Particulate Matter","Pulmonary Alveoli","Temperature","Thiazoles"],"mesh_terms":["Cell Line","Cell Membrane Permeability","Coumarins","Cytoplasm","Cytoskeleton","Diffusion","Humans","Models, Biological","Pulmonary Alveoli","Temperature","Thiazoles","Particulate Matter","Nanoparticles"],"keywords":["Chemistry","Intracellular","Cytoplasm","Biophysics","Cytoskeleton","Actin cytoskeleton","Fluorophore","Actin","Cytochalasin","Diffusion","Fluorescence","Biochemistry","Cell","Physics","Thermodynamics","Cell Membrane Permeability","Humans; Thiazoles; Temperature; Models, Biological; Nanoparticles; Cytoskeleton; Cytoplasm; Coumarins; Particulate Matter; Cell Membrane Permeability; Diffusion; Pulmonary Alveoli; Cell Line","Temperature","Solid Lipid Nanoparticles","Models, Biological","[PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]","Cell Line","Pulmonary Alveoli","Thiazoles","Fluorescence Microscopy","Molecular Motors","Coumarins","Humans","Nanoparticles","Particulate Matter"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-15T20:55:13.067581Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}