{"doi":"10.1016/j.bone.2008.05.015","title":"Relating osteon diameter to strain","abstract":null,"journal":"Bone","year":2008,"id":654136,"datarank":0.7156026936698499,"base_score":4.770684624465665,"endowment":4.770684624465665,"self_citation_contribution":0.7156026936698499,"citation_network_contribution":0.0,"self_endowment_contribution":0.7156026936698499,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":117,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1707120,"name":"Ronald Ruimerman","orcid":null,"position":1,"is_corresponding":false},{"id":705030,"name":"Bert van Rietbergen","orcid":"0000-0002-2278-2934","position":2,"is_corresponding":false},{"id":1707121,"name":"Peter A.J. Hilbers","orcid":null,"position":3,"is_corresponding":false},{"id":1707122,"name":"Rik Huiskes","orcid":null,"position":4,"is_corresponding":false},{"id":1707119,"name":"René F.M. van Oers","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Relating osteon diameter to strain","abstract":"Osteon diameter is generally smaller in bone regions that experience larger strains. A mechanism relating osteon diameter to strain is as yet unknown. We propose that strain-induced osteocyte signals inhibit osteoclastic bone resorption. This mechanism was previously shown to produce load-aligned osteons in computer simulations. Now we find that it also predicts smaller osteon diameter for higher loads. Additionally, we find that our model predicts osteon development with two cutting cones, one moving up and one moving down the loading axis. Such 'double-ended osteons' were reported in literature as a common type of osteon development. Further, we find that a steep gradient in strain magnitude can result in an osteonal tunnel with continuous resorption along the less strained side, which corresponds to 'drifting osteons' reported in literature.","is_dataset_classified":null,"base_score":4.770684624465665,"endowment":4.770684624465665,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18619937","pmcid":null,"openalex_id":"https://openalex.org/W2030535985","authors":[],"funders":[],"total_grants":0,"fwci":2.3615,"citation_percentile":0.88261479,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":5},{"year":2014,"count":10},{"year":2015,"count":8},{"year":2016,"count":4},{"year":2017,"count":6},{"year":2018,"count":11},{"year":2019,"count":10},{"year":2020,"count":9},{"year":2021,"count":8},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"https://www.elsevier.com/tdm/userlicense/1.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S8756328208002470?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S8756328208002470?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bone.2008.05.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18619937","host_type":"repository"},{"url":"https://research.tue.nl/en/publications/0e0c2985-fc98-4e95-9209-ed7585bb7e59","host_type":"repository"},{"url":"https://research.tue.nl/nl/publications/0e0c2985-fc98-4e95-9209-ed7585bb7e59","host_type":"repository"}],"fields_of_study":["Bone Metabolism and Diseases","Connective tissue disorders research","Bone health and treatments","Animals","Biochemistry","Biomechanical Phenomena","Bone Remodeling","Bone and Bones","Compressive Strength","Computer Simulation","Haversian System","Humans","Models, Statistical","Osteoblasts","Osteoclasts","Osteocytes","Stress, Mechanical","Tensile Strength"],"mesh_terms":["Animals","Biochemistry","Biomechanical Phenomena","Bone and Bones","Computer Simulation","Haversian System","Humans","Osteoblasts","Osteoclasts","Osteocytes","Stress, Mechanical","Tensile Strength","Models, Statistical","Bone Remodeling","Compressive Strength"],"keywords":["Osteon","Strain (injury)","Materials science","Osteocyte","Anatomy","Composite material","Chemistry","Cortical bone","Biology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T04:05:28.055895Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}