{"doi":"10.1016/j.bone.2006.04.016","title":"Vitamin D receptor gene BsmI and TaqI polymorphisms and fracture risk: A meta-analysis","abstract":"<h4>Introduction</h4>Fracture is the major clinical outcome of osteoporosis. The vitamin D receptor (VDR) gene is thought to be a candidate gene for osteoporosis. Many genetic studies have suggested an association of VDR polymorphisms and osteoporosis, but evidence remains conflicting.<h4>Materials and methods</h4>We searched published studies from 1996 to September 2005 through PubMed and evaluated the genetic effect of the BsmI and TaqI polymorphism of VDR on fracture risk in a meta-analysis. Thirteen studies with a total of 20 eligible comparisons (1632 fracture cases and 5203 controls) were analyzed with fixed and random effects models.<h4>Result</h4>No evidence of relationship between the VDR BsmI or TaqI polymorphism and fracture risk was observed with any genetic model. The odds ratio (95% confidence interval) of b-allele versus B-allele was 0.98 (0.86-1.12) with random effects calculations. There was significant between-study heterogeneity. Small studies did not differ significantly from larger ones.<h4>Conclusion</h4>No relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.","journal":"Bone","year":2006,"id":11658,"datarank":3.1989350771666403,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":2.5751026146626894,"self_endowment_contribution":0.6238324625039509,"citer_contribution":2.5751026146626894,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":63,"citers_with_citation_signal":55,"citers_with_endowment":55,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0443,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2006-10-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":16431,"name":"Fernando Rivadeneira","orcid":"0000-0001-9435-9441","position":1,"is_corresponding":false},{"id":94108,"name":"Huib A.P. Pols","orcid":null,"position":3,"is_corresponding":false},{"id":5303,"name":"André G. Uitterlinden","orcid":"0000-0002-7276-3387","position":5,"is_corresponding":false},{"id":16422,"name":"Joyce B. J. van Meurs","orcid":"0000-0001-6245-2123","position":6,"is_corresponding":false},{"id":44927,"name":"H. A. P. Pols","orcid":null,"position":7,"is_corresponding":false},{"id":148,"name":"John P. A. Ioannidis","orcid":"0000-0003-3118-6859","position":8,"is_corresponding":false},{"id":62863,"name":"Yue Fang","orcid":"0000-0002-2665-5027","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}