{"doi":"10.1016/j.bmcl.2023.129499","title":"Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1","abstract":null,"journal":"Bioorganic &amp; Medicinal Chemistry Letters","year":2023,"id":611911,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1058306,"name":"Nan Zhang","orcid":"0000-0001-7849-3974","position":1,"is_corresponding":false},{"id":1575233,"name":"Xianglong Kong","orcid":null,"position":2,"is_corresponding":false},{"id":516512,"name":"Nan Wang","orcid":"0009-0006-1132-8054","position":3,"is_corresponding":false},{"id":1575234,"name":"Hong-Gang Hu","orcid":null,"position":4,"is_corresponding":false},{"id":1575236,"name":"Wei Cong","orcid":null,"position":5,"is_corresponding":false},{"id":432879,"name":"Chao Liu","orcid":"0000-0003-0316-4994","position":6,"is_corresponding":false},{"id":1575232,"name":"Huaxing Shen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Benzyl stapled modification and anticancer activity of antimicrobial peptide A4K14-Citropin 1.1","abstract":"A4K14-Citropin 1.1 (GLFAVIKKVASVIKGL-NH<sub>2</sub>) is a derived antimicrobial peptide (AMP) with a more stable α-helical structure at the C-terminal compared to prototype Citropin 1.1 which was obtained from glandular skin secretions of Australian freetail lizards. In a previous report, A4K14-Citropin 1.1 has been considered as an anti-cancer lead compound. However, linear peptides are difficult to maintain stable secondary structure, resulted in poor pharmacokinetic properties. In this study, we designed and synthesized a series of benzyl-stapled derivatives of A4K14-Citropin 1.1. And their physical and chemical properties, as well as biological activity, were both explored. The result showed that AC-CCSP-2-o and AC-CCSP-3-o exhibited a higher degree of helicity and greater anti-cancer activity compared with the prototype peptide. Besides, there was no significant difference in the hemolytic effect between the stapled peptides and the prototype peptide. AC-CCSP-2-o and AC-CCSP-3-o could serve as promising anti-cancer lead compounds for the novel anti-cancer drug development.","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37804993","pmcid":null,"openalex_id":"https://openalex.org/W4387360149","authors":[],"funders":[{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"22140900300","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"22140900302","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"22140900303","title":null}],"total_grants":3,"fwci":1.2902,"citation_percentile":0.78737434,"influential_citations":0,"citation_trend":[{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0960894X23003773?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X23003773?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2023.129499","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37804993","host_type":"repository"}],"fields_of_study":["Antimicrobial Peptides and Activities","Biochemical and Structural Characterization","Lipid Membrane Structure and Behavior","Amphibian Proteins","Antimicrobial Cationic Peptides","Antimicrobial Peptides","Protein Conformation, alpha-Helical","Protein Structure, Secondary"],"mesh_terms":["Protein Conformation, alpha-Helical","Antimicrobial Peptides","Protein Structure, Secondary","Antimicrobial Cationic Peptides","Amphibian Proteins"],"keywords":["Chemistry","Peptide","Antimicrobial","Stereochemistry","Structure–activity relationship","Antimicrobial peptides","Combinatorial chemistry","Lead compound","Biological activity","In vitro","Biochemistry","Organic chemistry","AMP","Antimicrobial peptide","Anti-cancer activity","A4k14-Citropin 1.1","Thiol-halogen Click Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T23:43:49.526883Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}