{"doi":"10.1016/j.bmcl.2023.129172","title":"Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease","abstract":null,"journal":"Bioorganic & Medicinal Chemistry Letters","year":2023,"id":630279,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":364496,"name":"Ji Won Kim","orcid":"0000-0001-6459-5873","position":1,"is_corresponding":false},{"id":1632678,"name":"Girish Chandra","orcid":"0000-0002-8471-1517","position":2,"is_corresponding":false},{"id":1632679,"name":"Noriko Saito–Tarashima","orcid":"0000-0003-4552-5006","position":3,"is_corresponding":false},{"id":1632680,"name":"Yuhei Nogi","orcid":null,"position":4,"is_corresponding":false},{"id":1632681,"name":"Masashi Ota","orcid":null,"position":5,"is_corresponding":false},{"id":1632682,"name":"Noriaki Minakawa","orcid":null,"position":6,"is_corresponding":false},{"id":364500,"name":"Lak Shin Jeong","orcid":"0000-0002-3441-707X","position":7,"is_corresponding":false},{"id":364495,"name":"Jinha Yu","orcid":"0000-0002-0495-5686","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synthesis of oligonucleotides containing 5′-homo-4′-selenouridine derivative and its increased resistance against nuclease","abstract":"As technologies using RNA or DNA have been developed, various chemical modifications of nucleosides have been attempted to increase the stability of oligonucleotides. Since it is known that 2'-OMe-modification greatly contributes to increasing the stability of oligonucleotides, we added 2'-OMe to our previously developed 4'-selenonucleoside and 5'-homo-4'-selenonucleoside as the modified monomers for oligonucleotide: 2'-methoxy-4'-selenouridine (2'-OMe-4'-Se-U) and 5'-homo-2'-methoxy-4'-selenouridine (5'-homo-2'-OMe-4'-Se-U). We synthesized oligonucleotides containing the chemically modified 4'-selenouridine and evaluated their thermal stability and nuclease resistance. In conclusion, the nuclease stability of the oligonucleotide containing 5'-homo-2'-OMe-4'-selenouridine increased while its thermal stability decreased.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36746352","pmcid":null,"openalex_id":"https://openalex.org/W4319224653","authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2021M3E5E308084312","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2022R1C1C1004804","title":null}],"total_grants":2,"fwci":0.1868,"citation_percentile":0.43803284,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0960894X23000501?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0960894X23000501?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.bmcl.2023.129172","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36746352","host_type":"repository"}],"fields_of_study":["DNA and Nucleic Acid Chemistry","Advanced biosensing and bioanalysis techniques","RNA modifications and cancer"],"mesh_terms":["Oligonucleotides","RNA","Uridine","Organoselenium Compounds"],"keywords":["Oligonucleotide","Nuclease","Chemistry","Thermal stability","Monomer","Chemical stability","Chemical modification","DNA","Stereochemistry","Chemical synthesis","RNA","Combinatorial chemistry","Biochemistry","Organic chemistry","In vitro","Gene","Polymer","Thermostability","Nuclease resistance","5′-Homo-4′-selenonucleoside"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T20:49:08.098635Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}